{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:01:14Z","timestamp":1789891274037,"version":"4.0.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the potential clinical relevance of quantitative bone single-photon emission computed tomography combined with computed tomography (SPECT\/CT) in patients with ankle osteoarthritis (AOA), focusing on the relationship between radiotracer uptake and disease severity, as well as its correlation with preoperative subjective pain levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analyzed 44 patients with varus-type AOA who underwent preoperative bone SPECT\/CT between July 2018 and October 2024. All patients were classified according to the Takakura-Tanaka classification: stage 2 (n\u2009=\u20095), stage 3a (n\u2009=\u200915), stage 3b (n\u2009=\u200913), and stage 4 (n\u2009=\u200911). Quantitative parameters included the maximum standardized uptake value (SUVmax), SUVpeak, and total bone uptake (TBU), calculated at thresholds of 20% and 40% of SUVmax. Pain severity was assessed using the visual analog scale (VAS) within 1\u2009month of imaging. Group comparisons were performed using the Kruskal-Wallis test with Dunn post hoc analysis. Pearson correlation coefficient was used to assess associations between uptake values and VAS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both SUV and TBU values showed a general increase in accordance with advancing radiographic stage. In post hoc comparisons with Bonferroni correction, SUVmax and SUVpeak showed significant differences between stages 2 and 3b, stages 2 and 4, and stages 3a and 4 (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.0125), whereas 20%TBU and 40%TBU showed significant differences between stages 2 and 4 and stages 3a and 4 (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.0125). All 4 quantitative parameters demonstrated moderate correlations with preoperative VAS scores (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.49-0.55,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.0125), suggesting that both tracer uptake intensity and extent were associated with the patient\u2019s perceived pain levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Quantitative bone SPECT\/CT parameters were associated with radiographic severity in patients with varus-type ankle osteoarthritis. Exploratory analyses suggested moderate associations between radiotracer uptake parameters and preoperative pain, although these findings should be interpreted cautiously because VAS data were available only in a subset of patients. These results support further investigation of quantitative SPECT\/CT as a complement to conventional radiographic evaluation in AOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Level IV, retrospective case series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10711007261469177","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:44:37Z","timestamp":1787640277000},"page":"1170-1177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Bone SPECT\/CT in Varus-Type Ankle Osteoarthritis: Association With Radiographic Stage and Preoperative Pain"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-9910","authenticated-orcid":false,"given":"Kanu","family":"Shimokawa","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-1003","authenticated-orcid":false,"given":"Hidenori","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-7947","authenticated-orcid":false,"given":"Takayuki","family":"Shibutani","sequence":"additional","affiliation":[{"name":"Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Kayano","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1277-5200","authenticated-orcid":false,"given":"Yusuke","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-3802","authenticated-orcid":false,"given":"Satoru","family":"Demura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-019-00627-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2020.09.009"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjro.20230017"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100719898279"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003545"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06421-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B7.17325"},{"key":"e_1_3_3_9_2","article-title":"Introduction to xSPECT technology: evolving multimodal SPECT to become context-based and quantitative. White paper","author":"Vija AH.","year":"2013","unstructured":"Vija AH. Introduction to xSPECT technology: evolving multimodal SPECT to become context-based and quantitative. White paper. 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