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Ethics"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Cannabis use in some individuals can meaningfully introduce <jats:italic>de novo<\/jats:italic> risk for the initiation of opioid use and development of opioid use disorder. These risks may be particularly high during adolescence when cannabis use may disrupt critical periods of neurodevelopment. Current research studying the combination of genetic and environmental factors involved in substance use disorders is poorly understood. More research is needed, particularly to identify which adolescents are most at risk and to develop effective interventions addressing contributing factors such as trauma and psychiatric comorbidity.<\/jats:p>","DOI":"10.1177\/1073110520935338","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T04:57:54Z","timestamp":1594097874000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Cannabis as a Gateway Drug for Opioid Use Disorder"],"prefix":"10.1017","volume":"48","author":[{"given":"Arthur Robin","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"S1073110500026358_bib6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1405092"},{"key":"S1073110500026358_bib26","unstructured":"26. 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See Humphreys and Saitz, supra note 2"},{"key":"S1073110500026358_bib16","doi-asserted-by":"publisher","DOI":"10.1080\/1551806X.2016.1156455"},{"key":"S1073110500026358_bib22","unstructured":"22. Id."},{"key":"S1073110500026358_bib28","unstructured":"28. See Koob 2015, supra note 14."},{"key":"S1073110500026358_bib5","unstructured":"5. Szalavitz, M. , \u201cOnce and for All, Marijuana is Not a Gateway Drug,\u201d Vice News, October 13, 2015."},{"key":"S1073110500026358_bib17","unstructured":"17. See Koob 2015, supra note 14."},{"key":"S1073110500026358_bib25","unstructured":"25. See Kandel and Kandel, supra note 6."},{"key":"S1073110500026358_bib33","doi-asserted-by":"publisher","DOI":"10.1089\/can.2018.0021"},{"key":"S1073110500026358_bib35","unstructured":"35. See Ellgren et al., 2007 supra note 34."},{"key":"S1073110500026358_bib34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301127"},{"key":"S1073110500026358_bib43","unstructured":"43. 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