{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:31:27Z","timestamp":1777483887730,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"crossref","award":["FEMH 104-2314-B-418-009-MY2; FEMH-2018-C-010; FEMH"],"award-info":[{"award-number":["FEMH 104-2314-B-418-009-MY2; FEMH-2018-C-010; FEMH"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p>This study aimed to review clinical experiences using whole-field simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) and sequential IMRT in postoperative patients with oral cavity cancer (OCC). From November 2006 to December 2014, a total of 182 postoperative patients with OCC who underwent either SIB-IMRT (n = 63) or sequential IMRT (n = 119) were enrolled retrospectively and matched randomly according to multiple risk factors by a computer. The differences were well balanced after patient matching ( P = .38). The median follow-up time was 65 months. For patients treated with the SIB technique and the sequential technique, the respective mortality rates were 36.8% and 20.0% ( P = .04). The primary recurrence rates were 26.3% and 10.0% ( P = .02), respectively. The respective marginal failure rates were 26.7% and 16.7%. A multivariate logistic regression analysis showed that patients who received the SIB technique had a 2.74 times higher risk of death than those who received the sequential technique (95% confidence interval = 1.10-6.79, P = .03). Sequential IMRT provided a significantly lower dose to the esophagus (5.2 Gy, P = .02) and trachea (4.6 Gy, P = .03) than SIB-IMRT. For patients with locally advanced OCC, postoperative sequential IMRT may overcome an unpredictable geographic miss, potentially with a lower marginal failure rate in the primary area. Patients treated by sequential IMRT show equal overall survival benefits to those treated by SIB-IMRT and a lower mortality rate than those treated by SIB-IMRT. Additionally, a reduced dose to the esophagus and trachea compared to sequential IMRT was noted.<\/jats:p>","DOI":"10.1177\/1073274820904702","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T08:26:44Z","timestamp":1602577604000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Single-Institute Clinical Experiences Using Whole-Field Simultaneous Integrated Boost (SIB) Intensity-Modulated Radiotherapy (IMRT) and Sequential IMRT in Postoperative Patients With Oral Cavity Cancer (OCC)"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4695","authenticated-orcid":false,"given":"Chen-Hsi","family":"Hsieh","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C. (Republic of China)"},{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C. (Republic of China)"},{"name":"Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C. (Republic of China)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Wei","family":"Shueng","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C. (Republic of China)"},{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C. (Republic of China)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Physical Therapy Center, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. (Republic of China)"},{"name":"School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C. (Republic of China)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C. (Republic of China)"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan, R.O.C. (Republic of China)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Chia","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan, R.O.C. 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