{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:04Z","timestamp":1787019064762,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p>The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P &lt; 0.0001). The multivariate analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p &lt; 0.0001) was related to OS. Elevated preoperative LDH &gt;132 IU\/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.<\/jats:p>","DOI":"10.1177\/1073274820978795","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T13:52:24Z","timestamp":1607608344000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"27","author":[{"given":"Erliang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150081, China"},{"name":"*\u200a\u2009These two authors have contributed equally to the work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunhua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China"},{"name":"*\u200a\u2009These two authors have contributed equally to the work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"An","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese Academy of Medical Sciences Cancer Hospital. 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