{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:33:44Z","timestamp":1777484024307,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2018JJ2210"],"award-info":[{"award-number":["2018JJ2210"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>Pediatric solid tumors are heterogeneous and comprise various histological subtypes. TP53, a tumor suppressor, orchestrates the transcriptional activation of anti-cancer genes. The gene coding for this protein is highly polymorphic, and its mutations are associated with cancer development. The Arg72Pro polymorphism in TP53 has been associated with susceptibility to various types of cancer. Here, in this hospital-based study, we evaluated the association of this polymorphism with susceptibility toward malignant abdominal solid tumors in children in the Hunan province of China. We enrolled 162 patients with neuroblastoma, 60 patients with Wilms\u2019 tumor, and 28 patients with hepatoblastoma as well as 270 controls. Genotypes were determined using a TaqMan assay, and the strength of the association was assessed using an odds ratio, within a 95% confidence interval identified using logistic regression models. Our results showed that the Arg72Pro polymorphism did not exhibit significant association with susceptibility toward pediatric malignant abdominal solid tumors. Stratification analysis revealed that this polymorphism exerts weak sex- and age-specific effects on Wilms\u2019 tumor and hepatoblastoma susceptibility, respectively. Overall, our results indicate that the Arg72Pro polymorphism may have a marginal effect on susceptibility toward pediatric malignant abdominal solid tumors in Hunan, and this finding warrants further confirmation.<\/jats:p>","DOI":"10.1177\/10732748211004880","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T07:30:44Z","timestamp":1616571044000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Arg72Pro Polymorphism in\n                    <i>TP53<\/i>\n                    and Malignant Abdominal Solid Tumor Risk in Hunan Children"],"prefix":"10.1177","volume":"28","author":[{"given":"Zan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Emergency Center of Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":false,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-408X","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"bibr1-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0383-9"},{"key":"bibr2-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.474"},{"key":"bibr3-10732748211004880","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00798"},{"key":"bibr4-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2154"},{"key":"bibr5-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1038\/nature25480"},{"key":"bibr6-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000564"},{"key":"bibr7-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2017-0057"},{"key":"bibr8-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3526"},{"key":"bibr9-10732748211004880","doi-asserted-by":"publisher","DOI":"10.1097\/01720610-201011000-00005"},{"issue":"11","key":"bibr10-10732748211004880","first-page":"6079","volume":"37","author":"Pohl 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