{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:05:57Z","timestamp":1783602357373,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Student Innovation and Entrepreneurship Training Program of Shantou University College of Medicine","award":["201910560130"],"award-info":[{"award-number":["201910560130"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Esophagogastric junction adenocarcinoma (EJA) is one of the most common malignant tumors of digestive tract with high mortality worldwide. Given a lack of early diagnosis biomarkers, the prognosis of EJA is poor. Non-invasive biomarkers for early-stage EJA are urgently required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed at evaluating the early diagnostic value of serum interleukin-8 (IL-8) level in EJA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The IL-8 mRNA expression data were analyzed based on the stomach cardia adenocarcinoma samples of The Cancer Genome Atlas (TCGA) database. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentration of serum IL-8 in 95 EJA patients and 95 normal controls enrolled from 2 different cancer hospitals. The diagnostic accuracy of serum IL-8 was evaluated by applying Mann-Whitney U test and receiver operating characteristic (ROC) curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mRNA expression levels and serum levels of IL-8 in EJA group were significantly higher than those in the normal group (all P &lt; 0.001). The areas under the ROC curve (AUC) were 0.661 (95% CI, 0.583-0.740) and 0.745 (95% CI, 0.606-0.885), with the sensitivities of 43.2% (95% CI, 33.2%-53.7%) and 66.7% (95% CI, 46.0%-82.8%) and the specificities of 87.4% (95% CI, 78.6%-93.1%) in EJA group and early-EJA group, respectively, when the optimal cutoff value was 109.086 pg\/mL. The clinical data analysis showed there were significant correlations between patient genders, depth of invasion, lymph node metastasis, TNM stage and the serum level of IL-8 (all P &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Serum IL-8 represents a potential diagnostic biomarker to identify early-stage EJA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748211004883","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T03:23:41Z","timestamp":1619753021000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Early Diagnostic Value of Serum Interleukin-8 in Esophagogastric Junction Adenocarcinoma"],"prefix":"10.1177","volume":"28","author":[{"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Xu","sequence":"additional","affiliation":[{"name":"Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Yu","sequence":"additional","affiliation":[{"name":"Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cantong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Oncologic Pathology, Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University College of Medicine, Shantou, Guangdong, China"},{"name":"Precision Medicine Research Centre, Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-592X","authenticated-orcid":false,"given":"Yiwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University College of Medicine, Shantou, Guangdong, China"},{"name":"Precision Medicine Research Centre, Shantou University College of Medicine, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"bibr1-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-010-0555-2"},{"key":"bibr2-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2438"},{"key":"bibr3-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.04.013"},{"key":"bibr4-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27834"},{"key":"bibr5-10732748211004883","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.278"},{"key":"bibr6-10732748211004883","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i26.7933"},{"key":"bibr7-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1041"},{"key":"bibr8-10732748211004883","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i37.10573"},{"key":"bibr9-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-016-0268-6"},{"key":"bibr10-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1489-4"},{"key":"bibr11-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.027"},{"key":"bibr12-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.08.004"},{"key":"bibr13-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6252138"},{"key":"bibr14-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0760"},{"key":"bibr15-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28584"},{"key":"bibr16-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr216"},{"key":"bibr17-10732748211004883","doi-asserted-by":"crossref","unstructured":"Li J, Xu L, Run ZC, et al. Multiple cytokine profiling in serum for early detection of gastric cancer. World J Gastroenterol. 2018;24(21):2269-2278. doi:10.3748\/wjg.v24.i21.2269","DOI":"10.3748\/wjg.v24.i21.2269"},{"key":"bibr18-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/962320"},{"key":"bibr19-10732748211004883","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i1.16"},{"key":"bibr20-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20616"},{"key":"bibr21-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603446"},{"key":"bibr22-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01577-7"},{"key":"bibr23-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04709.x"},{"key":"bibr24-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04110.x"},{"key":"bibr25-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41338.x"},{"key":"bibr26-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.043976"},{"key":"bibr27-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.514"},{"key":"bibr28-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2835-1"},{"key":"bibr29-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2012.09.008"},{"key":"bibr30-10732748211004883","doi-asserted-by":"publisher","DOI":"10.7150\/thno.15625"},{"key":"bibr31-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-3-11"},{"key":"bibr32-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517726441"},{"key":"bibr33-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4997"},{"key":"bibr34-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29561"},{"key":"bibr35-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00048-0"},{"key":"bibr36-10732748211004883","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150716105255"},{"key":"bibr37-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12206"},{"key":"bibr38-10732748211004883","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0894-y"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748211004883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748211004883","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748211004883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:22:01Z","timestamp":1777386121000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748211004883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":38,"alternative-id":["10.1177\/10732748211004883"],"URL":"https:\/\/doi.org\/10.1177\/10732748211004883","relation":{},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"article-number":"10732748211004883"}}