{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:35:06Z","timestamp":1777484106072,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients\u2019 management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan\u2013Meier survival curve method, and comparisons between groups were performed by the Log-rank\/Gray test methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\/conclusion<\/jats:title>\n                    <jats:p>In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748211038429","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T05:01:04Z","timestamp":1637211664000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project"],"prefix":"10.1177","volume":"28","author":[{"given":"Mohammad A. J.","family":"Abdulla","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Chandra","sequence":"additional","affiliation":[{"name":"Medical Research Center, Biostatistics Section, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna El","family":"Akiki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood B.","family":"Aldapt","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundus","family":"Sardar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammar","family":"Chapra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulqadir J.","family":"Nashwan","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Sorio","sequence":"additional","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Tomasello","sequence":"additional","affiliation":[{"name":"Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Boni","sequence":"additional","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-8076","authenticated-orcid":false,"given":"Mohamed A.","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"bibr1-10732748211038429","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"bibr2-10732748211038429","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.745525"},{"key":"bibr3-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16599"},{"key":"bibr4-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"bibr5-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2375.bloodjournal8872375"},{"key":"bibr6-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204693"},{"key":"bibr7-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2410.bloodjournal8872410"},{"key":"bibr8-10732748211038429","volume-title":"Wintrobe\u2019s Clinical Hematology","author":"Greer J","year":"2019","edition":"14"},{"key":"bibr9-10732748211038429","unstructured":"World Health Organization. https:\/\/www.who.int\/data\/gho\/data\/themes\/theme-details\/GHO\/body-mass-index-(bmi), 2020."},{"key":"bibr10-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz045"},{"key":"bibr11-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0028"},{"key":"bibr12-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501569"},{"issue":"12","key":"bibr13-10732748211038429","first-page":"839","volume":"4","author":"Tefferi A","year":"1990","journal-title":"Leukemia"},{"key":"bibr14-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08362.x"},{"issue":"5","key":"bibr15-10732748211038429","first-page":"BR193","volume":"8","author":"Prejzner W","year":"2002","journal-title":"Med Sci Mon Int Med J Exp Clin Res"},{"issue":"4","key":"bibr16-10732748211038429","first-page":"803","volume":"4","author":"De Lemos JA","year":"2005","journal-title":"Genet Mol Res"},{"key":"bibr17-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V110.11.1939.1939"},{"key":"bibr18-10732748211038429","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.009134"},{"key":"bibr19-10732748211038429","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.096537"},{"key":"bibr20-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-674242"},{"key":"bibr21-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12597"},{"key":"bibr22-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24774"},{"key":"bibr23-10732748211038429","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2018.19.6.1479"},{"key":"bibr24-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31977"},{"key":"bibr25-10732748211038429","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_726_17"},{"key":"bibr26-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-019-0139-2"},{"key":"bibr27-10732748211038429","doi-asserted-by":"publisher","DOI":"10.6026\/97320630010108"},{"key":"bibr28-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1875818"},{"key":"bibr29-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1159\/000507295"},{"issue":"3","key":"bibr30-10732748211038429","first-page":"2","volume":"92","author":"Ali E","year":"2021","journal-title":"Acta Biomed"},{"key":"bibr31-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1177\/1073274820976594"},{"key":"bibr32-10732748211038429","volume":"2021","author":"Yassin MA","journal-title":"Survey of Ophthalmology"},{"key":"bibr33-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1177\/10732748211009256"},{"key":"bibr34-10732748211038429","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3738"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748211038429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748211038429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748211038429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:22:11Z","timestamp":1777386131000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748211038429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":34,"alternative-id":["10.1177\/10732748211038429"],"URL":"https:\/\/doi.org\/10.1177\/10732748211038429","relation":{},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"10732748211038429"}}