{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:53:08Z","timestamp":1784220788789,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Gansu Province Science Foundation for Distinguished Young Scholars","award":["1606RJDA317"],"award-info":[{"award-number":["1606RJDA317"]}]},{"name":"Foundation of The First Hospital of Lanzhou University","award":["ldyyyn2017-29"],"award-info":[{"award-number":["ldyyyn2017-29"]}]},{"name":"Health Industry Research Project of Gansu Province","award":["GSWSKY2016-10"],"award-info":[{"award-number":["GSWSKY2016-10"]}]},{"name":"Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province","award":["zdsyskfkt-201704"],"award-info":[{"award-number":["zdsyskfkt-201704"]}]},{"name":"Lanzhou University serves Gansu Province Economic and Social Development Special Research Project","award":["0411181424"],"award-info":[{"award-number":["0411181424"]}]},{"name":"First Hospital of Lanzhou University","award":["ldyyyn2017-08"],"award-info":[{"award-number":["ldyyyn2017-08"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although\u00a0 Helicobacter pylori\u00a0(Hp) as high risk factor for gastric cancer have been investigated from human trial, present data is inadequate to explain the effect of Hp on the changes of metabolic phenotype of gastric cancer in different stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Herein, plasma of human superficial gastritis (Hp negative and positive), early gastric cancer and advanced gastric cancer analyzed by UPLC-HDMS metabolomics can not only reveal metabolic phenotype changes in patients with gastric cancer of different degrees (30 Hp negative, 30 Hp positive, 20 early gastric cancer patients, and 10 advanced gastric cancer patients), but also auxiliarily diagnose gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Combined with multivariate statistical analysis, the results represented biomarkers different from Hp negative, Hp positive, and the alterations of metabolic phenotype of gastric cancer patients. Forty-three metabolites are involved in amino acid metabolism, and lipid and fatty acid metabolism pathways in the process of cancer occurrence, especially 2 biomarkers glycerophosphocholine and neopterin, were screened in this study. Neopterin was consistently increased with gastric cancer progression and glycerophosphocholine tended to consistently decrease from Hp negative to advanced gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This method could be used for the development of rapid targeted methods for biomarker identification and a potential diagnosis of gastric cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748211041881","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T09:20:26Z","timestamp":1632648026000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-1063","authenticated-orcid":false,"given":"Yan-Ping","family":"Wang","sequence":"first","affiliation":[{"name":"The Pharmacy Department, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wei","sequence":"additional","affiliation":[{"name":"The Pharmacy Department, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"The Traditional Chinese Medicine Laboratory, Gansu Institute for Drug Control, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Liang","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Fei","family":"Ren","sequence":"additional","affiliation":[{"name":"The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Hui","family":"Ding","sequence":"additional","affiliation":[{"name":"The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Tian","family":"Bai","sequence":"additional","affiliation":[{"name":"The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Xiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Miao","sequence":"additional","affiliation":[{"name":"The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ce","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Meng","sequence":"additional","affiliation":[{"name":"The Department of Minimally invasive surgery, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Research Center, Gansu Cancer Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"bibr1-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60617-6"},{"key":"bibr2-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"bibr3-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.04.008"},{"key":"bibr4-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2857"},{"key":"bibr5-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0584"},{"key":"bibr6-10732748211041881","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.107"},{"key":"bibr7-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61283-w"},{"issue":"7","key":"bibr8-10732748211041881","first-page":"11052","volume":"8","author":"Cheng Y","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr9-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21562"},{"key":"bibr10-10732748211041881","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.648338"},{"key":"bibr11-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0493-8"},{"key":"bibr12-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17921-x"},{"key":"bibr13-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.414"},{"key":"bibr14-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-3317-4"},{"key":"bibr15-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.335"},{"key":"bibr16-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-016-1050-5"},{"key":"bibr17-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1021\/ac051437y"},{"key":"bibr18-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09329-0"},{"key":"bibr19-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25294"},{"key":"bibr20-10732748211041881","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i25.8092"},{"key":"bibr21-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-008-6132-9"},{"key":"bibr22-10732748211041881","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.4000"},{"key":"bibr23-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.04.001"},{"key":"bibr24-10732748211041881","doi-asserted-by":"publisher","DOI":"10.3109\/08941930903410783"},{"key":"bibr25-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.260"},{"key":"bibr26-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01840-3"},{"issue":"3","key":"bibr27-10732748211041881","first-page":"761","volume":"19","author":"Beutner U","year":"2008","journal-title":"Oncol Rep"},{"key":"bibr28-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024143"},{"key":"bibr29-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-690"},{"key":"bibr30-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.5.1142"},{"key":"bibr31-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.6b00281"},{"key":"bibr32-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.04.005"},{"key":"bibr33-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2070-4"},{"key":"bibr34-10732748211041881","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005892"},{"key":"bibr35-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-122"},{"key":"bibr36-10732748211041881","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01289.x"},{"key":"bibr37-10732748211041881","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.11"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748211041881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748211041881","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748211041881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:22:14Z","timestamp":1777386134000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748211041881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"alternative-id":["10.1177\/10732748211041881"],"URL":"https:\/\/doi.org\/10.1177\/10732748211041881","relation":{},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"10732748211041881"}}