{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:35:58Z","timestamp":1777484158812,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Jiangsu Province Youth Medical Talent Development","award":["QNRC2016400"],"award-info":[{"award-number":["QNRC2016400"]}]},{"name":"The Six peak talents in Jiangsu Province","award":["YY-177"],"award-info":[{"award-number":["YY-177"]}]},{"name":"The Project of Nantong Youth Medical Talent Development","award":["05"],"award-info":[{"award-number":["05"]}]},{"name":"The Nantong Science and Technology Bureau","award":["MS22018007, MS22018010, MS22019021, JCZ18116, JCZ18057, MSZ18269"],"award-info":[{"award-number":["MS22018007, MS22018010, MS22019021, JCZ18116, JCZ18057, MSZ18269"]}]},{"name":"The Health Bureau of Nantong City","award":["WKZL2018057, MB2021057"],"award-info":[{"award-number":["WKZL2018057, MB2021057"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As a new class of non-coding RNAs, circRNAs have been recently reported to be involved in the tumorigenesis and progression of human cancers. In the current study, we attempted to explore the potential function of a novel circRNA (hsa_circ_0013290) in hepatocellular carcinoma (HCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relative hsa_circ_0013290 expression was analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The subcellular location of hsa_circ_0013290 was performed by RNA subcellular isolation and fluorescence in situ hybridization (FISH) assays. The effect of hsa_circ_0013290 on proliferation was detected by Cell Counting Kit-8 (CCK-8) assays. The effect of hsa_circ_0013290 on cell cycle distribution and apoptosis was detected by flow cytometry. The invasion and migration abilities of hsa_circ_0013290 were detected by transwell assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hsa_circ_0013290 is significantly upregulated in HCC cell lines and mainly located in cytoplasm of HCC cells. Hsa_circ_0013290 overexpression promotes cell invasion and migration and inhibits cell apoptosis. In contrast, hsa_circ_0013290 knockdown impedes cell invasion and migration and accelerates cell apoptosis. However, hsa_circ_0013290 did not affect cell proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hsa_circ_0013290 is overexpressed in HCC cell lines and is mainly located in the cytoplasm of HCC cells. Hsa_circ_0013290 promotes cell invasion and migration, and inhibits cell apoptosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748211055681","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T02:53:07Z","timestamp":1637376787000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hsa_circ_0013290 Acts as Cancer-Promoting Gene in Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7288-6870","authenticated-orcid":false,"given":"Xi","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Third People\u2019s Hospital of Nantong, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicun","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong University, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong University, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiaochun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong University, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Third People\u2019s Hospital of Nantong, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong Institute of Liver Disease, The Third People\u2019s Hospital of Nantong, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linling","family":"Ju","sequence":"additional","affiliation":[{"name":"Nantong Institute of Liver Disease, The Third People\u2019s Hospital of Nantong, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Third People\u2019s Hospital of Nantong, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-6497","authenticated-orcid":false,"given":"Zhaolian","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Third People\u2019s Hospital of Nantong, Nantong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"bibr1-10732748211055681","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"bibr2-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1713263"},{"key":"bibr3-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"bibr4-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0663-2"},{"key":"bibr5-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01213-6"},{"key":"bibr6-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0902-1"},{"key":"bibr7-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2028-9"},{"key":"bibr8-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1128065"},{"key":"bibr9-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz757"},{"key":"bibr10-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1248"},{"key":"bibr11-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035"},{"key":"bibr12-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1038\/280339a0"},{"key":"bibr13-10732748211055681","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100836"},{"key":"bibr14-10732748211055681","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1041-z"},{"issue":"6","key":"bibr15-10732748211055681","first-page":"1167","volume":"6","author":"Wang 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