{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:33:14Z","timestamp":1783114394450,"version":"3.54.6"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hainan Provincial Natural Science and Technology Foundation","award":["NO. 819QN369"],"award-info":[{"award-number":["NO. 819QN369"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the feasibility, safety, and efficacy of computed tomography(CT)-guided percutaneous radiofrequency ablation (RFA) in medically inoperable older adults with clinical stage I non-small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the records of medically inoperable older adults (\u226570\u00a0years) with clinical stage I NSCLC who underwent percutaneous multi-tined electrode RFA at our institution between January 2014 and December 2018. We analyzed the patients\u2019 characteristics, therapy response, survival, as well as the procedure-related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen patients (10 men and 8 women) with a mean age of 75.9 (71\u221285)\u00a0years were treated in during the study period. The median tumor size was 25\u00a0mm (range, 19\u221243\u00a0mm); 10 and 8 cases involved stage T1 and T2a disease, respectively. The median follow-up duration was 25 (11\u201345)\u00a0months. RFA was technically successful for all 18 lesions, with no treatment-related mortality. The disease control rate was 83.3% (15\/18 lesions). There were 6 cases of pneumothorax: one symptomatic case requiring thoracic drainage, and five requiring no treatment. Minor complications, including pulmonary infection, chest pain, fever, and cough, were treated within 4\u00a0days (range, 1\u22124\u00a0days). The progression-free survival rates were 83.3%, 64.9%, and 51.9% 1, 2, and 3\u00a0years, respectively. The corresponding overall survival rates were 92.2%, 81.5%, and 54.3%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CT-guided percutaneous RFA is safe and effective in medically inoperable patients with stage I NSCLC and could be an alternative therapeutic strategy, particularly in older adults with early-stage peripheral lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748211070702","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:33:32Z","timestamp":1643103212000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Computed Tomography-Guided Percutaneous Radiofrequency Ablation in Older Adults With Early-Stage Peripheral Lung Cancer: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6595-1259","authenticated-orcid":false,"given":"Yanda","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicines, Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangzheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Hainan Medical University, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"bibr1-10732748211070702","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1155"},{"key":"bibr3-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.8.628"},{"key":"bibr4-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)00909-6"},{"key":"bibr5-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.08.011"},{"key":"bibr6-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.005"},{"key":"bibr7-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.06.040"},{"key":"bibr8-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.10.078"},{"key":"bibr9-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20539"},{"key":"bibr10-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717x-3-36"},{"key":"bibr11-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1097\/rti.0000000000000212"},{"key":"bibr12-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1007\/s40134-019-0340-x"},{"key":"bibr13-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-020-01361-1"},{"key":"bibr14-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000004350"},{"key":"bibr15-10732748211070702","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-010-0562-2"},{"key":"bibr16-10732748211070702","doi-asserted-by":"publisher","DOI":"10.4055\/cios19179"},{"issue":"4","key":"bibr17-10732748211070702","first-page":"293","volume":"6","author":"Allan 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