{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:49:18Z","timestamp":1790084958120,"version":"4.0.1"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Data about the risk factors and pancreatic cancer in developing countries remain limited. We investigated for the first time the role of a number of risk factors (family cancer history, smoking, alcohol consumption, diabetes, inflammation disease, HBV infection) associated with pancreatic cancer among Vietnamese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included all patients hospitalized at 4 Northern Vietnamese hospitals (Vietnam National Cancer Hospital, Bach Mai, Viet Duc, Thai Nguyen) and diagnosed with pancreatic cancer during the period from 2017 to 2019. Risk factors of eligible patients were collected and assessed the associations using a matched control study and logistic regression model analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 196 patients with diagnosis of pancreatic cancer of which 114 males and 82 females. The average age of the patient at the time of diagnosis was 58.28 years (standard deviation of 12.94, ranging from 25 to 87). Most of patients were diagnosed at advanced stage (85%). Smoking, diabetes, inflammation disease significantly increased the cancer risks (OR and 95% CI were 2.42 (1.38-4.37), 3.09 (1.54-6.68), 2.21 (1.42-3.45), respectively). HBV infection demonstrated a significant link with pancreatic cancer in univariate model (OR = 2.94 (1.08-9.36)), but not in multivariate model. However, cancer family history and alcohol drinkers did not show any significantly increased risk related to pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our finding showed smoking, diabetes, inflammation disease significantly increased the risk of pancreatic cancer in Vietnam.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1073274821989320","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T04:26:19Z","timestamp":1612153579000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors of Pancreatic Cancer in Vietnam: A Matched Case\u2013Control Hospital-Based Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Thuan","family":"Van Tran","sequence":"first","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Hanoi Medical University, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-8347","authenticated-orcid":false,"given":"Tu","family":"Van Dao","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-6135","authenticated-orcid":false,"given":"Khac-Dung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"To","family":"van TA","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Hanoi Medical University, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh Truong","family":"Vu","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son Hong","family":"Trinh","sequence":"additional","affiliation":[{"name":"Viet Duc Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Cong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Thai Nguyen National General Hospital, Thai Nguyen, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-759X","authenticated-orcid":false,"given":"Oanh Thi","family":"Bui","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Tien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoan Duc","family":"Vu","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiep Le","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-0895","authenticated-orcid":false,"given":"Huong Thanh","family":"Tran","sequence":"additional","affiliation":[{"name":"Vietnam National Cancer Hospital, Hanoi, Vietnam"},{"name":"Hanoi Medical University, Hanoi, Vietnam"},{"name":"Vietnam National Cancer Institute, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"bibr1-1073274821989320","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-1073274821989320","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"bibr3-1073274821989320","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0880"},{"key":"bibr4-1073274821989320","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp466"},{"key":"bibr5-1073274821989320","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"bibr6-1073274821989320","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"bibr7-1073274821989320","unstructured":"SEER. 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