{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:24:05Z","timestamp":1788539045563,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007941","name":"Addis Ababa University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007941","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Ethiopian Public Health Institute"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the performance of visual inspection with acetic acid compared with Human papillomavirus Deoxyribonucleic acid (HPV DNA) testing among women with HIV in Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comparative cross-sectional study was conducted to address the aforementioned objective. Data were collected from January to October 2021, to compare the performance of these two screening modalities. Trained clinicians collected cervical specimens and immediately applied acetic acid for visual inspection. The HPV DNA testing was done using Abbott m2000rt\/SP by trained laboratory professionals in accredited laboratories. A total of 578 women with HIV aged 25-49\u00a0years were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Test positivity was 8.9% using visual inspection with acetic acid (VIA) and 23.3% using HPV DNA test. The sensitivity and specificity of the VIA test were 19.2% and 95.1%, respectively. The strength of agreement between the two screening methods was poor (k = .184). The burden of genetic distribution of high risk HPV16 was 6.1%, and HPV18 was 1.1%. Other high risk HPV types (ie non-HPV 16\/18 high risk HPV genotypes) were predominant in this study (18.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The higher positivity result using HPV DNA testing compared with VIA, and low sensitivity of VIA are indicating that the implementation of HPV DNA testing as the primary screening strategy is likely to reduce cervical cancer cases and deaths of women in the country.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748221114980","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T10:01:13Z","timestamp":1657706473000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Performance of visual Inspection With Acetic Acid for Cervical Cancer Screening as Compared to Human papillomavirus Deoxyribonucleic acid Testing Among Women With HIV in Ethiopia: A Comparative Cross-sectional Study"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-8251","authenticated-orcid":false,"given":"Agajie Likie","family":"Bogale","sequence":"first","affiliation":[{"name":"Program of Tropical and Infectious Diseases, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia; and staff and researcher at the Ethiopian Public Health Institute, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilahun","family":"Teklehaymanot","sequence":"additional","affiliation":[{"name":"Program of Tropical and Infectious Diseases, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getnet Mitike","family":"Kassie","sequence":"additional","affiliation":[{"name":"International Institute of Primary Health Care-Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girmay","family":"Medhin","sequence":"additional","affiliation":[{"name":"Program of Tropical and Infectious Diseases, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemal Haidar","family":"Ali","sequence":"additional","affiliation":[{"name":"School of public health, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nega Berhe","family":"Belay","sequence":"additional","affiliation":[{"name":"Program of Tropical and Infectious Diseases, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"bibr1-10732748221114980","volume-title":"Plan of Action for Cervical Cancer Prevention and Control 2018-2030","author":"Pan American Health Organization","year":"2018"},{"key":"bibr2-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2018.1439917"},{"key":"bibr3-10732748221114980","unstructured":"The Global Cancer Observatory, \u201cReport. Ethiop. Source Globocan. 2020; pp. 1-2, 2021."},{"key":"bibr4-10732748221114980","unstructured":"Bruni L, Albero G, Serrano B, et al. ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Ethiopia. Summary Report. Accessed October 22, 2021."},{"key":"bibr5-10732748221114980","unstructured":"Who Guidance Note. Comprehensive Cervical Cancer Prevention and Control: A Healthier Future for Girls and Women. WHO; 2013;1-12, ISBN 978 9."},{"key":"bibr6-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29458"},{"key":"bibr7-10732748221114980","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13027-020-00323-6","volume":"15","author":"Orang\u2019o EO","year":"2020","journal-title":"Infect Agents Cancer"},{"key":"bibr8-10732748221114980","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.138165"},{"key":"bibr9-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218559"},{"key":"bibr10-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0156"},{"key":"bibr11-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1594-x"},{"key":"bibr12-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084519"},{"key":"bibr13-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2004.02.015"},{"key":"bibr14-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0874-7"},{"key":"bibr15-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00351.x"},{"key":"bibr16-10732748221114980","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12646"},{"key":"bibr17-10732748221114980","first-page":"1","volume-title":"Abbott RealTime High Risk HPV","author":"WHO","year":"2014"},{"key":"bibr18-10732748221114980","unstructured":"World Health Organization. Guidelines for Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention. 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