{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:39:07Z","timestamp":1777484347970,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000138","name":"U.S. Department of Education","doi-asserted-by":"publisher","award":["P031S150048"],"award-info":[{"award-number":["P031S150048"]}],"id":[{"id":"10.13039\/100000138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA54174OD"],"award-info":[{"award-number":["P30CA54174OD"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"School of Nursing Advisory Council at the University of Texas Health Science Center","award":["Internal Research Grant"],"award-info":[{"award-number":["Internal Research Grant"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24\u00a0weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-\u03b3 (INF-\u03b3), interleukin-12 (IL-12), interleukin-1\u03b1 (IL-1\u03b1), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-\u03b1), and vascular endothelial growth factor (VEGF), distanced walked during a 6-minute walk test (6MWT), body mass index, and health-related quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 \u00b1 198.66, post: 80.29 \u00b1 124.30, P = .06) and INF-\u03b3 (pre: 152.88 \u00b1 312.71, post: 118.93 \u00b1 158.79, P = .08), in the intervention group; only IL- \u03b1 (pre: 332.15 \u00b1 656.77, post: 255.12 \u00b1 502.09, P = .20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748221130964","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T05:32:46Z","timestamp":1665034366000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active Surveillance"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-5952","authenticated-orcid":false,"given":"Crisann","family":"Moon","sequence":"first","affiliation":[{"name":"Biobehavioral Laboratory, School of Nursing, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber M.","family":"Gallegos","sequence":"additional","affiliation":[{"name":"Biobehavioral Laboratory, School of Nursing, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Biobehavioral Laboratory, School of Nursing, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratap","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Medicine, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Liss","sequence":"additional","affiliation":[{"name":"School of Medicine, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darpan I.","family":"Patel","sequence":"additional","affiliation":[{"name":"Biobehavioral Laboratory, School of Nursing, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA"},{"name":"Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"bibr1-10732748221130964","volume-title":"Surveillance, Epidemiology, and End Results Program (SEER) cancer stat facts: Prostate cancer","author":"National Cancer Institute","year":"2021"},{"key":"bibr2-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.03.006"},{"key":"bibr3-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1586"},{"key":"bibr4-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001903"},{"key":"bibr5-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00120.x"},{"key":"bibr6-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12452"},{"key":"bibr7-10732748221130964","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102984"},{"key":"bibr8-10732748221130964","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.688489"},{"key":"bibr9-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.9"},{"key":"bibr10-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0707"},{"key":"bibr11-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001454"},{"key":"bibr12-10732748221130964","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2019.8520"},{"key":"bibr13-10732748221130964","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.08.187"},{"key":"bibr14-10732748221130964","first-page":"332","author":"Schulz KF","year":"2010","journal-title":"CONSORT Group. 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