{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:48Z","timestamp":1790709348483,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>The worldwide CML incidence expects 100,000 patients every year thus representing a substantial health burden. A year 2000 is notable year, where Tyrosine kinase inhibitors (TKIs) had been introduced to the CML treatment plan. However, despite the dramatically reduce in mortality rate of CML patients due to TKIs, still over 25% of CML patients need to switch TKIs at least once during treatment timeline for many reasons. On the other hand, PTPRG behave as a tumor suppressor gene in different neoplasms and is strongly down-regulated in CML patients. We discussed briefly in series of articles the possible reasons of it is down regulation. Here, we discuss its role as potential therapeutic target in treatment plan.<\/jats:p>","DOI":"10.1177\/10732748221140201","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T04:39:29Z","timestamp":1668573569000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Protein Tyrosine Phosphatase Receptor Gamma as Potential Therapeutic Target for Chronic Myeloid Leukemia Patients"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-856X","authenticated-orcid":false,"given":"Mohamed A.","family":"Ismail","sequence":"first","affiliation":[{"name":"School of Life Science, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University London, London, UK"},{"name":"Interim Translational Research Institute (iTRI), Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Sorio","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Al-Dewik","sequence":"additional","affiliation":[{"name":"Interim Translational Research Institute (iTRI), Hamad Medical Corporation (HMC), Doha, Qatar"},{"name":"Department of Research, Women\u2019s Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar"},{"name":"Faculty of Health and Social Care Sciences, Kingston University, St. George\u2019s University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"bibr1-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1039\/C6IB00127K"},{"issue":"6","key":"bibr2-10732748221140201","first-page":"581","volume":"22","author":"Moradi F","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"bibr3-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.851"},{"key":"bibr4-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01436-6"},{"key":"bibr5-10732748221140201","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194820"},{"key":"bibr6-10732748221140201","doi-asserted-by":"publisher","DOI":"10.4137\/BIC.S31427"},{"key":"bibr7-10732748221140201","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S32822"},{"key":"bibr8-10732748221140201","volume-title":"Recent Developments in Chronic Myeloid Leukemia Biology and Treatment","author":"Sorio MBC","year":"2018"},{"key":"bibr9-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0109"},{"key":"bibr10-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0258"},{"key":"bibr11-10732748221140201","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24253"},{"key":"bibr12-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0494-z"},{"key":"bibr13-10732748221140201","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072298"},{"key":"bibr14-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1319"},{"key":"bibr15-10732748221140201","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179899"},{"issue":"8833","key":"bibr16-10732748221140201","first-page":"1","volume":"11","author":"Ismail MA","year":"2021","journal-title":"Sci Rep"},{"key":"bibr17-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.5427.5427"},{"key":"bibr18-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.146101"},{"key":"bibr19-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-485573"},{"key":"bibr20-10732748221140201","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401841"},{"key":"bibr21-10732748221140201","doi-asserted-by":"publisher","DOI":"10.3390\/biom12010084"},{"key":"bibr22-10732748221140201","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.768969"},{"key":"bibr23-10732748221140201","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00665"},{"key":"bibr24-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2020.106337"},{"key":"bibr25-10732748221140201","doi-asserted-by":"publisher","DOI":"10.2174\/1389450114666140106095151"},{"key":"bibr26-10732748221140201","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500093"},{"issue":"4","key":"bibr27-10732748221140201","first-page":"3597","volume":"20","author":"Kaufman-Szymczyk A","year":"2019","journal-title":"Mol Med Rep"},{"key":"bibr28-10732748221140201","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001462"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748221140201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748221140201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748221140201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:22:56Z","timestamp":1777386176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748221140201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":28,"alternative-id":["10.1177\/10732748221140201"],"URL":"https:\/\/doi.org\/10.1177\/10732748221140201","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10732748221140201\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748221140201\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748221140201\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748221140201\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748221140201\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748221140201\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748221140201\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"article-number":"10732748221140201"}}