{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:42:44Z","timestamp":1777484564174,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007632","name":"Changhua Christian Hospital","doi-asserted-by":"publisher","award":["111-CCH-HCR-142"],"award-info":[{"award-number":["111-CCH-HCR-142"]}],"id":[{"id":"10.13039\/501100007632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Using mammographic density as a significant biomarker for predicting prognosis in adjuvant hormone therapy patients is controversial due to the conflicting results of recent studies. This study aimed to evaluate hormone therapy-induced mammographic density reduction and its association with prognosis in Taiwanese patients .<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 1941 patients with breast cancer were screened, and 399 patients with estrogen receptor -positive breast cancer who received adjuvant hormone therapy were enrolled. The mammographic density was measured using a fully automatic estimation procedure based on full-field digital mammography. The prognosis included relapse and metastasis during treatment follow-up. The Kaplan-Meier method and Cox proportional hazards model were used for disease-free survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A mammographic density reduction rate &gt;20.8%, measured preoperatively and after receiving hormone therapy from 12-18 months, was a significant threshold for predicting prognosis in patients with breast cancer. The disease-free survival rate was significantly higher in patients whose mammographic density reduction rate was &gt;20.8% (P = .048).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study\u2019s findings could help estimate the prognosis for patients with breast cancer and may improve the quality of adjuvant hormone therapy after enlarging the study cohort in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748231160991","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T05:09:22Z","timestamp":1677820162000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mammographic Density Reduction is Associated to the Prognosis in Asian Breast Cancer Patients Receiving Hormone Therapy"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-840X","authenticated-orcid":false,"given":"Wei-Chung","family":"Shia","sequence":"first","affiliation":[{"name":"Molecular Medicine Laboratory, Department of Research, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, The Affiliated Hospital (Group) of Putian University, Putian, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa-Koon","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"},{"name":"Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-4374","authenticated-orcid":false,"given":"Dar-Ren","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"bibr1-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197605)37:5<2486::aid-cncr2820370542>3.0.co;2-8"},{"key":"bibr2-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju078"},{"key":"bibr3-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2942"},{"key":"bibr4-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013091.pub2"},{"key":"bibr5-10732748231160991","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13484"},{"key":"bibr6-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3221"},{"key":"bibr7-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69297-3_14"},{"key":"bibr8-10732748231160991","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215391"},{"key":"bibr9-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh106"},{"key":"bibr10-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2789"},{"key":"bibr11-10732748231160991","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31816956c3"},{"issue":"4","key":"bibr12-10732748231160991","first-page":"1327","volume":"32","author":"Smith 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