{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:42:16Z","timestamp":1781239336164,"version":"3.54.1"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key research and development program of Zhejiang province","doi-asserted-by":"crossref","award":["2019C03010"],"award-info":[{"award-number":["2019C03010"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hangzhou Medical and health science and Technology Project","award":["0020190447"],"award-info":[{"award-number":["0020190447"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of chemotherapy-induced neutropenia (CIN) in epithelial ovarian carcinoma (EOC) treated with primary surgery followed by platinum-based chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The records of primary EOC treated between Jan 1\n                      <jats:sup>st<\/jats:sup>\n                      2002 and Dec 31\n                      <jats:sup>st<\/jats:sup>\n                      2016 were reviewed according to the including and excluding criteria. CIN was defined as absolute neutrophil count (ANC) after chemotherapy &lt;2.0 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L. Patients with CIN were further divided into mild and severe CIN (ANC &lt;1.0 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L), early-onset and late-onset (&gt;3 cycles) CIN. Clinical characteristic was compared by chi-square test. Overall survival (OS) and progression-free survival (PFS) were compared using Kaplan\u2013Meier analysis, univariate and multivariate Cox regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 735 EOC patients enrolled, no significant differences of the prognosis were found between patients with and without CIN, early and late CIN, mild and severe CIN. However, Kaplan\u2013Meier curve (65 vs 42\u00a0months for CIN vs non-CIN, P = .007) and Cox regression analysis (HR 1.499, 95% CI 1.142-1.966; P = .004) both revealed that CIN was significantly related with better OS in advanced EOC patients, but not for PFS. So, subgroup analysis was further conducted and date suggested that CIN was an independent predictor of better survival in advanced EOC with suboptimal surgery (PFS: 18 vs 14\u00a0months, P = .013, HR 1.526, 95% CI 1.072-2.171, P = .019; OS: 37 vs 27 months, P = .013, HR 1.455, 95% CI 1.004-2.108; P = .048).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CIN might be used as an independent prognostic indicator of advanced EOC, especially for those patients with suboptimal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748231183496","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T02:03:10Z","timestamp":1688349790000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemotherapy-Induced Neutropenia as a Prognostic Factor in Patients With Advanced Epithelial Ovarian Carcinoma"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-4384","authenticated-orcid":false,"given":"Yaping","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, China"},{"name":"Hangzhou Red Cross Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2230-8693","authenticated-orcid":false,"given":"Mingjing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-2974","authenticated-orcid":false,"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital School of Medicine Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou, Zhejiang, 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