{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:44:14Z","timestamp":1777484654265,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of Sardinia, Italy, to describe the incidence of myeloid malignancies overall (N = 4389 cases) and by subtype. We investigated the time trend of acute myeloid leukemia (N = 1227 cases), chronic myeloid leukemia (N = 613 cases), and myelodysplastic syndrome (N = 1296 cases), and used Bayesian methods to explore their geographic spread, and Poisson regression analysis to estimate their association with environmental and socio-economic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The annual standardized (world population) incidence rate (IR) of myeloid malignancies over the study period was 6.5 per 100,000 (95% CI 6.2-6.7). Myelodysplastic syndromes were the most prevalent subgroup (IR = 1.7, 95% CI 1.5-1.8). Incidence of all myeloid malignancies combined increased sharply during the study period with an annual percent change (APC) of 10.06% (95% CI 9.51-10.61), 19.77% for myelodysplastic syndromes (95% CI 19.63-19.91), and 3.18% (95% CI 2.99-3.37) for acute myeloid leukemia. Chronic myeloid leukemia did not show an upward trend. Apart from sporadic excesses in small rural communities and the major urban area, there was no evidence of spatial clustering. The risk of myeloid malignancies increased with increasing prevalence of sheep breeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results might prompt further research on the local genetic and environmental determinants of myeloid hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748231202906","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T07:16:48Z","timestamp":1698218208000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy"],"prefix":"10.1177","volume":"30","author":[{"given":"Giorgio","family":"Broccia","sequence":"first","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplants, Hospital A. Businco, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Carter","sequence":"additional","affiliation":[{"name":"University of Coventry, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansu","family":"Ozsin-Ozler","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry, Faculty of Dentistry, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"De Matteis","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-7614","authenticated-orcid":false,"given":"Pierluigi","family":"Cocco","sequence":"additional","affiliation":[{"name":"Division of Public Health, Health Services Research & Primary Care, Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"bibr1-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282632"},{"key":"bibr2-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.450"},{"key":"bibr3-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32034"},{"key":"bibr4-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32034"},{"key":"bibr5-10732748231202906","doi-asserted-by":"publisher","DOI":"10.5144\/1658-3876.2011.161"},{"key":"bibr6-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1200\/GO.21.00194"},{"key":"bibr7-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1200\/GO.21.00194"},{"key":"bibr8-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03734-6"},{"key":"bibr9-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2022.106839"},{"key":"bibr10-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961009)68:2<156::AID-IJC2>3.0.CO;2-X"},{"key":"bibr11-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1515\/9780691187266"},{"key":"bibr12-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-2002-z"},{"issue":"1","key":"bibr13-10732748231202906","first-page":"41","volume":"36","author":"Cocco P","year":"2012","journal-title":"Epidemiol Prev"},{"key":"bibr14-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260078"},{"key":"bibr15-10732748231202906","unstructured":"The Haematologic Malignancies Research Network. Classification of haematologic malignancies. 2022. https:\/\/hmrn.org\/about\/classification"},{"key":"bibr16-10732748231202906","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"bibr17-10732748231202906","volume-title":"The International Classification of Diseases for Oncology","author":"Fritz A","year":"2013","edition":"3"},{"key":"bibr18-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2006.00528.x"},{"key":"bibr19-10732748231202906","unstructured":"Regional Agency for the Environmental Protection in Sardinia (ARPAS). [Report on the environmental radioactivity in Sardinia. Autonomous Region of Sardinia, 2019]. 2019; https:\/\/www.sardegnaambiente.it\/documenti\/21_393_20210427155604.pdf. Accessed 10 December 2022."},{"key":"bibr20-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1080\/17445647.2015.1084544"},{"issue":"1","key":"bibr21-10732748231202906","first-page":"5","volume":"30","author":"Biggeri A","year":"2006","journal-title":"Epidemiol Prev"},{"key":"bibr22-10732748231202906","unstructured":"LAORE. Agenzia Regionale per lo Sviluppo in Agricoltura [Data on cattle, sheep, and goat farms in Sardinia - 2019]. 2019; http:\/\/sardegnaagricoltura.it\/documenti(2020). Accessed 30 November 2022."},{"key":"bibr23-10732748231202906","volume-title":"International Agency for Research on Cancer","author":"Curado MP","year":"2007"},{"key":"bibr24-10732748231202906","first-page":"1","volume":"179","author":"Ingram DD","year":"2018","journal-title":"Vital Health Stat"},{"key":"bibr25-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06745-z"},{"key":"bibr26-10732748231202906","doi-asserted-by":"publisher","DOI":"10.7150\/jca.52186"},{"key":"bibr27-10732748231202906","doi-asserted-by":"publisher","DOI":"10.5045\/br.2021.2021187"},{"issue":"2","key":"bibr28-10732748231202906","first-page":"43","volume":"76","author":"Kazieva KE","year":"1998","journal-title":"Klin Med (Mosc)"},{"issue":"3","key":"bibr29-10732748231202906","first-page":"174","volume":"82","author":"Godon D","year":"1991","journal-title":"Can J Public Health"},{"key":"bibr30-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81579-9"},{"key":"bibr31-10732748231202906","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.80.10.1209"},{"key":"bibr32-10732748231202906","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051006"},{"key":"bibr33-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1007\/BF00572231"},{"key":"bibr34-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32202"},{"key":"bibr35-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.2.106"},{"key":"bibr36-10732748231202906","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19148643"},{"key":"bibr37-10732748231202906","doi-asserted-by":"publisher","DOI":"10.19191\/EP19.2-3.S1.032.43"},{"key":"bibr38-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2011.09.001"},{"key":"bibr39-10732748231202906","volume-title":"Zoonoses and Communicable Diseases Common to Man and Animals","author":"Acha PN","year":"2003","edition":"3"},{"key":"bibr40-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3891-9"},{"key":"bibr41-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27908"},{"key":"bibr42-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112979"},{"key":"bibr43-10732748231202906","unstructured":"Cirronis G, ed. [20 years of Blue Tongue in Sardinia.] Sardegna, ieri, oggi e domani. 2021; https:\/\/www.sardegnaierioggidomani.com\/economia\/20-anni-di-blue-tongue-in-sardegna-coldiretti-sardegna-800mila-pecore-morte-e-166-milioni-di-euro-di-indennizzi\/. Accessed 5 March 2022."},{"key":"bibr44-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117069"},{"key":"bibr45-10732748231202906","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1969.1"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748231202906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748231202906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748231202906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:23:45Z","timestamp":1777386225000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748231202906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":45,"alternative-id":["10.1177\/10732748231202906"],"URL":"https:\/\/doi.org\/10.1177\/10732748231202906","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10732748231202906\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748231202906\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"10732748231202906"}}