{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:41:50Z","timestamp":1790563310726,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hebei Province Key Research and Development Program","award":["19277770D"],"award-info":[{"award-number":["19277770D"]}]},{"name":"Hebei Province Administration of Traditional Chinese Medicine","award":["2023020"],"award-info":[{"award-number":["2023020"]}]},{"name":"Health and Family Planning Commission of Hebei","award":["20180686"],"award-info":[{"award-number":["20180686"]}]},{"name":"Health and Family Planning Commission of Hebei","award":["20180688"],"award-info":[{"award-number":["20180688"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Radiation-induced oropharyngeal injury is a dose-limiting toxicity in head and neck cancer patients. Delineation of the \u201coropharyngeal mucosa\u201d and limiting its dose to spare the oropharynx was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, computed tomography imaging from eight patients with previously untreated head and neck cancer was employed. An adaptive contouring brush within the planning software Monaco was used to create an air cavity within the oropharynx, and then the air cavity was expanded uniformly 2\u00a0mm to create the \u201coropharyngeal mucosa\u201d. Three plans were independently generated for each patient: Plan1: dose constraint was applied for the oropharynx; Plan2: dose constraints were applied for the oropharynx and the \u201coropharyngeal mucosa\u201d; Plan3: dose constraint was applied for the \u201coropharyngeal mucosa\u201d. T-tests were used to compare the dosimetry variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All plans had adequate target coverage and there were no statistical differences among plans. The mean dose, D30%, D45%, D50%, D85%, D90%, D95%, D100%, V25\u00a0Gy, V30\u00a0Gy, V35\u00a0Gy, V40\u00a0Gy, and V45\u00a0Gy of the oropharynx and \u201coropharyngeal mucosa\u201d in Plan1 were significantly higher than those in Plan2 and Plan3. There were no significant differences between Plan2 and Plan3. There were no significant differences in the dosimetric parameters of any other organs at risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Delineation of the \u201coropharyngeal mucosa\u201d and limiting its dose should be an easy and effective method to spare the oropharynx.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748241283621","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T01:23:14Z","timestamp":1726276994000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Delineation of the \u201cOropharyngeal Mucosa\u201d and Limiting its Dose in Head and Neck Cancer Patients Spares the Oropharynx Without Compromising Target Coverage"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-5977","authenticated-orcid":false,"given":"Xueqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diancheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China"},{"name":"Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research (Hebei), Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"bibr1-10732748241283621","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"bibr2-10732748241283621","doi-asserted-by":"publisher","DOI":"10.1016\/S1001-9294(15)30047-X"},{"issue":"4","key":"bibr3-10732748241283621","first-page":"149","volume":"28","author":"Liang X","year":"2020","journal-title":"Hong Kong J Dermatol"},{"key":"bibr4-10732748241283621","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-018-1227-z"},{"key":"bibr5-10732748241283621","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.011"},{"key":"bibr6-10732748241283621","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.068569"},{"key":"bibr7-10732748241283621","unstructured":"NCCN Head and Neck Cancers\n                      . 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