{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:37:44Z","timestamp":1777905464531,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cytoreductive surgery is critical for optimal tumor clearance in advanced epithelial ovarian cancer (EOC). Despite best efforts, some patients may experience R2 (&gt;1\u00a0cm) resection, while others may not undergo surgery at all. We aimed to compare outcomes between advanced EOC patients undergoing R2 resection and those who had no surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data from 51 patients with R2 resection were compared to 122 patients with no surgery between January 2015 and December 2019 at a UK tertiary referral centre. Progression-free survival (PFS) and overall survival (OS) were the study endpoints. Principal Component Analysis and Term Frequency \u2013 Inverse Document Frequency scores were utilized for data discrimination and prediction of R&gt;2\u00a0cm from computed tomography pre-operative reports, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistical significance was observed, except for age (73 vs 67\u00a0years in the no- surgery vs R2 group, P: .001). Principal Components explained 34% of data variances. Reasons for no surgery included age, co-morbidities, patient preference, refractory disease, patient deterioration or disease progression, and absence of measurable intra- abdominal disease). The median PFS and OS were 12 and 14\u00a0months for no-surgery, vs 14 and 26\u00a0months for R2 ( P: .138 and P: .001, respectively). Serous histology and performance status independently predicted PFS in both no-surgery and R2 cohorts. In the no-surgery cohort, serous histology independently predicted OS, while in the R2 cohorts, both serous histology and adjuvant chemotherapy were independent prognostic features for OS. The bi-grams \u201cabdominopelvic ascites\u201d and \u201csolid omental\u201d were amongst those best discriminating between R&gt;2\u00a0cm and R1-2\u00a0cm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>R2 resection and no-surgery cohorts displayed unfavourable prognosis with a notable degree of uniformity. When cytoreduction results in suboptimal results, the survival benefit may still be higher compared to those who underwent no surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748241285480","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T07:31:30Z","timestamp":1726558290000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Survival Dynamics in Advanced Ovarian Cancer: R2 Resection Versus No-Surgery Paths Explored"],"prefix":"10.1177","volume":"31","author":[{"given":"Konstantinos","family":"Pitsikakis","sequence":"first","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-674X","authenticated-orcid":false,"given":"Diederick","family":"DeJong","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Kitsos-Kalyvianakis","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2680-0442","authenticated-orcid":false,"given":"Marios Evangelos","family":"Mamalis","sequence":"additional","affiliation":[{"name":"Information Systems Lab, Department of Business Administration, University of Macedonia, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishath","family":"Shavee","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Leeds, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Wahab","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Leeds, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amudha","family":"Thangavelu","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Broadhead","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Nugent","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Kalampokis","sequence":"additional","affiliation":[{"name":"Information Systems Lab, Department of Business Administration, University of Macedonia, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-7393","authenticated-orcid":false,"given":"Alexandros","family":"Laios","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, ESGO Centre of Excellence for ovarian cancer surgery, St James's University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"bibr1-10732748241285480","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"bibr2-10732748241285480","unstructured":"Griffiths CT. Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma\n                      1\n                      c. thomas griffiths 2 summary-the effect of tumor bulk resection on survival was studied in 102 patients with stages ii and iii ovarian cancer. a multiple linear regression equation provided both simultane. In: Symposium on Ovarian Carcinoma, November 15 and 16, 1974, Reston, Virginia. 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