{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:42:37Z","timestamp":1777484557230,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Total pelvic exenteration (TPE) for clinical T4b colorectal cancer (CRC) is associated with significant morbidity. Short (0-30\u00a0days)- and intermediate (31-90\u00a0days)-term temporal analysis of complication onset is not well described, yet needed, to better counsel patients considering TPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of consecutive patients with primary or recurrent clinical T4b pelvic CRC undergoing open TPE between 2014 and 2023 was conducted. Clinicopathologic variables were collected for each patient. Postoperative morbidity was classified according to the Clavien-Dindo (CD) grade system and stratified by time of onset within 90\u00a0days of surgery. Pearson\u2019s Chi-square test, Fisher\u2019s Exact test, and the Mann-Whitney U test were used to compare primary vs recurrent patient groups, and logistic regression assessed predictors of postoperative morbidity. Statistical analysis was performed using R with two-sided significance set at &lt;0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-seven patients were identified of which 24 (88.9%) were male with a median age of 60.4\u00a0years (interquartile range [IQR]: 56.3-70.5). Seventeen (63.0%) patients had primary disease and 10 (37.0%) had recurrent CRC. Twenty-three (85.2%) patients experienced at least one complication within 90 days of surgery, but no mortality was observed. Ten (37.0%) patients experienced a CD \u2265 3 event, of which 40% took place beyond 30\u00a0days. The most common complication overall was anemia requiring transfusion, while the most common major complication was pelvic abscess. No clinicopathologic variables analyzed were predictive of major postoperative complication within 90\u00a0days of TPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TPE for clinical T4b CRC carries a high risk of postoperative morbidity in both the short- and intermediate-term after surgery, with a significant proportion of complications occurring after 30\u00a0days. Given the magnitude of operation, an extended recovery with high risk for complications is common. Although a single-center series, this annotated postoperative complication profile may assist patients and clinicians when reviewing informed consent for TPE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251316598","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T18:35:17Z","timestamp":1737657317000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Short- and Intermediate-Term Morbidity Following Total Pelvic Exenteration in Colorectal Cancer"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1399-2688","authenticated-orcid":false,"given":"Christopher","family":"Guske","sequence":"first","affiliation":[{"name":"University of South Florida, Morsani College of Medicine, Tampa, FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9928-6195","authenticated-orcid":false,"given":"Nusheen","family":"Immen","sequence":"additional","affiliation":[{"name":"Judy Genshaft Honors College, University of South Florida, Tampa, FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devon","family":"Conant","sequence":"additional","affiliation":[{"name":"Non-Therapeutic Research Operations, H. Lee Moffitt Cancer Center, Tampa, FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Laborde","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Linscott","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Behzad","family":"Jazayeri","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Fazili","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dessureault","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Stefanou","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Manley","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Felder","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"bibr1-10732748251316598","volume-title":"StatPearls","author":"Lotfollahzadeh S","year":"2023"},{"key":"bibr2-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02893.x"},{"key":"bibr3-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194807)1:2<177::aid-cncr2820010203>3.0.co;2-a"},{"key":"bibr4-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10734"},{"key":"bibr5-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002528"},{"key":"bibr6-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1994.01420280062008"},{"key":"bibr7-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1007\/BF02660766"},{"key":"bibr8-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16817"},{"key":"bibr9-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.12.472"},{"key":"bibr10-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6462-1"},{"key":"bibr11-10732748251316598","volume-title":"Colon and Rectal Surgery: Abdominal Operations","author":"Felder S","year":"2018","edition":"2"},{"key":"bibr12-10732748251316598","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr13-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"bibr14-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.08.011"},{"key":"bibr15-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07816-8"},{"key":"bibr16-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31827a7868"},{"key":"bibr17-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-279"},{"key":"bibr18-10732748251316598","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2019.06.03"},{"key":"bibr19-10732748251316598","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040550"},{"key":"bibr20-10732748251316598","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.749"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251316598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748251316598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251316598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:23:25Z","timestamp":1777386205000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748251316598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"alternative-id":["10.1177\/10732748251316598"],"URL":"https:\/\/doi.org\/10.1177\/10732748251316598","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10732748251316598\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251316598\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251316598\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251316598\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251316598\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251316598\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251316598\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"10732748251316598"}}