{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:42:41Z","timestamp":1777484561663,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shanghai Top Priority Research Center Construction Program","award":["2022ZZ01011"],"award-info":[{"award-number":["2022ZZ01011"]}]},{"name":"First Affiliated Hospital of Naval Medical University"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A few studies have examined whether the safety and efficacy of moderate hypofractionated post-prostatectomy radiotherapy (moderate HYPORT, also called MYSTERY) are equal to those of conventionally fractionated post-prostatectomy radiotherapy (COPORT) in patients with localized prostate cancer. Therefore, this study aims to compare the safety and efficacy of MYSTERY and COPORT in patients with postoperative prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This study is a prospective, single-center, open-label, randomized controlled clinical trial. Patients with localized prostate cancer will be randomly allocated to receive COPORT (66-74\u00a0Gy at 2\u00a0Gy per fraction) or MYSTERY (57.5-65\u00a0Gy at 2.5\u00a0Gy per fraction). The primary outcomes are radiotherapy-related gastrointestinal and genitourinary adverse events. Secondary outcomes include progression-free survival, quality of life, medical expenses, and overall survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251317682","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T19:41:45Z","timestamp":1739302905000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Moderate Hypofractionated Post-Prostatectomy Radiotherapy (MYSTERY) Versus Conventionally Fractionated Post-Prostatectomy Radiotherapy (COPORT) for the Patients With Localized Prostate Cancer: The Protocol of a Prospective, Randomized Trial"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4328-6116","authenticated-orcid":false,"given":"Yiyin","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 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Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"bibr1-10732748251317682","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"bibr2-10732748251317682","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.01.006"},{"key":"bibr3-10732748251317682","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00243-0"},{"key":"bibr4-10732748251317682","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0050"},{"key":"bibr5-10732748251317682","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.23.2760"},{"key":"bibr6-10732748251317682","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.8525"},{"key":"bibr7-10732748251317682","volume-title":"Clinical Practice Guidelines in Oncology[EB]\/\/Prostate Cancer, Version 4","author":"National Comprehensive Cancer Network 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