{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:45:46Z","timestamp":1791585946259,"version":"4.3.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical Research Fund For Distinguished Youth Scholars of Peking University Cancer Hospital","award":["QNJJ202419"],"award-info":[{"award-number":["QNJJ202419"]}]},{"name":"Peking University Medicine Sailing Program for Young Scholars\u2019 Scientific & Technological Innovation","award":["BMU2023YFJHPY022"],"award-info":[{"award-number":["BMU2023YFJHPY022"]}]},{"name":"Science Foundation of Peking University Cancer Hospital","award":["BJCH2024CZ09"],"award-info":[{"award-number":["BJCH2024CZ09"]}]},{"name":"Science Foundation of Peking University Cancer Hospital","award":["ZY202506"],"award-info":[{"award-number":["ZY202506"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2020-2-1027"],"award-info":[{"award-number":["2020-2-1027"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82073333"],"award-info":[{"award-number":["82073333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Hospitals Authority\u2019s Ascent Plan","award":["DFL20220902"],"award-info":[{"award-number":["DFL20220902"]}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science &Technology Commission","doi-asserted-by":"crossref","award":["Z181100001718192"],"award-info":[{"award-number":["Z181100001718192"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Hospitals Authority Clinical medicine Development of special funding support","doi-asserted-by":"crossref","award":["ZLRK202327"],"award-info":[{"award-number":["ZLRK202327"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Local advanced rectal cancer (LARC) patients who achieved pathological complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) generally have a favorable prognosis. This retrospective study aimed to evaluate the prognostic value of magnetic resonance imaging (MRI) parameters and neutrophil-to-lymphocyte ratio (NLR) in LARC patients with pCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2015 and 2019, 180 LARC patients who achieved pCR after NCRT and surgery were included. MRI parameters and NLR were evaluated as potential predictors for 5-year overall survival (OS) and disease-free survival (DFS) using the Kaplan\u2013Meier and COX regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With a median follow-up time of 68.3\u00a0months, the 5-year OS and DFS rates were 94.2% and 91.4%, respectively. Thirteen patients (7.2%) died, 2 (1.1%) experienced local recurrence, and 15 (8.3%) experienced distant metastases. Pretreatment MRI parameters and NLR were correlated with 5-year OS and DFS in pCR patients in the univariate analysis. The multivariate analysis identified baseline EMVI and NLR as independent predictors for 5-year OS and DFS (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Patients in the low-risk group (EMVI-negative and\/or NLR \u2264 2.8, n = 159, 88.3%) had a more favorable 5-year DFS compared to those in the high-risk group (EMVI-positive and NLR &gt; 2.8, n = 21, 11.7%) (95.6% vs 59.4%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), with similar findings for 5-year OS (97.4% vs 70.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed that MRI parameters and NLR were associated with long-term prognosis in patients with pCR. These findings could aid in stratifying pCR patients and guide subsequent treatment and follow-up strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251334454","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:22:37Z","timestamp":1744816957000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pretreatment MRI Parameters and Neutrophil-to-Lymphocyte Ratio Could Predict the Long-Term Prognosis of Locally Advanced Rectal Cancer Patients With Pathological Complete Response after Neoadjuvant Chemoradiotherapy"],"prefix":"10.1177","volume":"32","author":[{"given":"Yujun","family":"Cui","sequence":"first","affiliation":[{"name":"Peking University Cancer Hospital & Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University Cancer Hospital & 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