{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:31:56Z","timestamp":1781375516673,"version":"3.54.1"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Shanghai Shenkang Three-Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals:","award":["SHDC2022CRD009"],"award-info":[{"award-number":["SHDC2022CRD009"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82205009"],"award-info":[{"award-number":["82205009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Shanghai Municipal Health Commission Clinical Research Project","award":["20214Y0178"],"award-info":[{"award-number":["20214Y0178"]}]},{"name":"Shanghai Hospital Collaborative Innovation Centre for Industrial Transformation of Chinese Pharmaceutical Preparations project"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Papillary thyroid carcinoma (PTC) generally has a favorable prognosis, yet advanced PTC has higher recurrence and mortality risks. This study constructs and validates a competing risk model for cause-specific mortality (CSM) in advanced PTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Stage III-IV PTC cases (AJCC 7th edition) from the SEER database (2010-2015) were analyzed. Patients were split into training and validation sets (7:3). Univariate and multivariate analyses identified independent CSM predictors, forming the basis of a risk prediction nomogram. Model accuracy was evaluated via the C-index and calibration curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 11\u00a0913 advanced PTC cases were analyzed. Competing risk model analysis unraveled that age, race, sex, grade, stage, T stage, M stage, surgery, chemotherapy, and tumor size were risk factors for CSM in advanced PTC. The AUC values of the constructed nomogram in predicting 3-, 5-, and 8-year survival were 0.931 (95%CI 0.909-0.953), 0.915 (95%CI 0.897-0.933), and 0.902 (95%CI 0.883-0.92) in the training set, and 0.948 (95%CI 0.916-0.981), 0.93 (95 % CI 0.903-0.957), and 0.917 (95%CI 0.891-0.943) in the validation cohort, respectively. The C-index of the nomogram for advanced PTC was 0.908 and 0.921 in the training and validation cohorts, respectively. The calibration curve unveiled that the predicted estimates by the model were basically congruent with the observed values, suggesting a high degree of calibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The competing risk model offers a reliable tool for assessing prognosis in advanced PTC, supporting personalized treatment and risk management in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251336412","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:29:11Z","timestamp":1745436551000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of Risk Factors for Cause-specific Mortality in Advanced Papillary Thyroid Cancer and Construction of a Competing Risk Model: A SEER-Based Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-2901","authenticated-orcid":false,"given":"Yunyi","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Qu","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufa","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Fu","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"You","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijin","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215581"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00360"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29289"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.043"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.783439"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0007"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031015"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0073"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0033"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14673"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0626"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0433"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.852347"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3190"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.545078"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2012.03.007"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078378"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7594"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1423-5"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.8759"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep27086"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07636-0"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(94)90425-1"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2021.11.009"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32832ff2cb"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2019-0051"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.17843\/rpmesp.2020.372.4892"},{"key":"e_1_3_5_30_2","first-page":"79","article-title":"Multifactorial analysis of survival and recurrences in differentiated thyroid cancer. Comparative evaluation of usefulness of AGES, MACIS, and risk group scores in Mexican population","volume":"21","author":"Rodr\u00edguez-Cuevas S","year":"2002","unstructured":"Rodr\u00edguez-Cuevas S, Labastida-Almendaro S, Cort\u00e9s-Arroyo H, L\u00f3pez-Garza J, Barroso-Bravo S. Multifactorial analysis of survival and recurrences in differentiated thyroid cancer. Comparative evaluation of usefulness of AGES, MACIS, and risk group scores in Mexican population. J Exp Clin Cancer Res. 2002;21:79-86.","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2019-0385"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21653"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0060"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.11.010"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113212"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31814697d9"},{"key":"e_1_3_5_37_2","first-page":"53","article-title":"New guidelines for the management of thyroid nodules and differentiated thyroid cancer","volume":"36","author":"Milas Z","year":"2011","unstructured":"Milas Z, Shin J, Milas M. New guidelines for the management of thyroid nodules and differentiated thyroid cancer. Minerva Endocrinol. 2011;36:53-70.","journal-title":"Minerva Endocrinol"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0068"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47898-8"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-N1412"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.12.029"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251336412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748251336412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251336412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:23:39Z","timestamp":1777386219000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748251336412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":40,"alternative-id":["10.1177\/10732748251336412"],"URL":"https:\/\/doi.org\/10.1177\/10732748251336412","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10732748251336412\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251336412\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251336412\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251336412\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251336412\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251336412\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251336412\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"article-number":"10732748251336412"}}