{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:43:56Z","timestamp":1777484636949,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteoporosis increases fracture risk and mortality, and cancer treatments worsen bone loss. Although mGPS is a common inflammatory-nutritional marker in oncology, its role in predicting osteoporosis is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional retrospective study analyzed 93 cancer patients aged \u226550 who underwent dual-energy X-ray absorptiometry (DXA) scans within a year of the first chemotherapy allocation. The results were categorized into groups regarding T-score as normal (T \u2265 \u22121.0), osteopenia (\u22122.5 &lt; T &lt; \u22121.0), and osteoporosis (T \u2264 \u22122). Patients were categorized based on mGPS and body mass index (BMI), and regression analysis was performed to identify predictors of osteoporosis in the lumbar spine, femur neck, and total femur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the patients, 61.3% were female, the median age was 61 years, 41.9% had osteoporosis in the lumbar spine, and 49.5% had osteopenia in the femoral neck. A significant association was observed between BMI and osteoporosis, with higher BMI linked to lower osteoporosis prevalence, particularly in the femur regions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .03). There were no significant associations between bone density in the lumbar spine\/femoral neck\/total femur and age, gender, disease stage, type of chemotherapy, or BMI (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values &gt;.05). A significant association between mGPS and bone density was observed in the lumbar spine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001) and femur total (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). In the lumbar spine, patients with an mGPS score of 0 had the highest proportion of normal bone density (71.4%), while those with an mGPS score of 2 had a higher prevalence of osteoporosis (55.6%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001). In the femur total, 46.7% of patients with an mGPS score of 2 were classified with osteoporosis, compared to only 8.5% of those with an mGPS score of 0 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 001). Patients with an mGPS score of 2 were over six times more likely to have osteoporosis in the lumbar spine (OR = 6.25,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.027). In the femur total, an mGPS score of 2 also significantly predicted osteoporosis (OR = 5.472,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mGPS is a cost-effective and reliable tool for predicting osteoporosis in elderly cancer patients, enabling early interventions. Integrating it into routine assessments could enhance patient outcomes by addressing osteoporosis risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251337601","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:32:51Z","timestamp":1745397171000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting Osteoporosis in Elderly Cancer Patients Using the Modified Glasgow Prognostic Index"],"prefix":"10.1177","volume":"32","author":[{"given":"Muge","family":"Ustuner","sequence":"first","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0077-6971","authenticated-orcid":false,"given":"Sabin","family":"Goktas Aydin","sequence":"additional","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-768X","authenticated-orcid":false,"given":"Ahmet","family":"Aydin","sequence":"additional","affiliation":[{"name":"Istanbul Medipol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Ozguzel","sequence":"additional","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eda Nur","family":"Duran","sequence":"additional","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Kadioglu","family":"Yeniyurt","sequence":"additional","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Senocak Tasci","sequence":"additional","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Bayramova","sequence":"additional","affiliation":[{"name":"Istanbul SBU Kanuni Sultan Suleyman Training and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2020.06.004"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2023.386"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-022-02872-1"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-022-02581-w"},{"key":"e_1_3_5_7_2","first-page":"47","article-title":"Magnesium metabolism and its disorders","volume":"24","author":"Swaminathan R","year":"2003","unstructured":"Swaminathan R. 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