{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:44:01Z","timestamp":1777484641077,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["202511\/2015-4"],"award-info":[{"award-number":["202511\/2015-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["140134\/2017-4"],"award-info":[{"award-number":["140134\/2017-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pain is a common adverse event of chemotherapy in pediatric oncology patients. Understanding pain\u2019s impact on these patients is essential for improving their quality of life and treatment outcomes. This short communication aims to describe the characteristics of pain in children with Acute Lymphoblastic Leukemia (ALL) and to explore its interactions with hospitalization duration and relapse, considering variables such as age, gender, and risk level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed data from 610 observations of pediatric patients with ALL treated under the Brazilian GBTLI-99 protocol. Pain was recorded according to CTCAE criteria. Statistical analyses, including Chi-square, Mann-Whitney, Poisson, and logistic regression models, were applied to explore associations between pain, hospitalization length, relapse, and other variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results indicated that patients who presented with pain experienced longer hospitalization lengths. No significant difference in the presence of pain in female or male pediatric patients was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is a first step towards treating pain as a limiting event that compromises the quality of life and response to treatment in Brazilian pediatric cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251341522","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:36:28Z","timestamp":1747809388000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pain as an Adverse Event During Chemotherapy in Children with Acute Lymphoblastic Leukemia: A Cross-Sectional Nationwide Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-2333","authenticated-orcid":false,"given":"Fernanda Machado","family":"Silva-Rodrigues","sequence":"first","affiliation":[{"name":"Department of Maternal-Infant and Psychiatric Nursing, School of Nursing, University of S\u00e3o Paulo, S\u00e3o Paulo - SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela S.","family":"Hinds","sequence":"additional","affiliation":[{"name":"George Washington University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-789X","authenticated-orcid":false,"given":"Carlos Alberto","family":"Scrideli","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Regina","family":"Brandalise","sequence":"additional","affiliation":[{"name":"Dr. Domingos A. Boldrini Children's Center for Hematologic Research, Boldrini Center, Campinas - SP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alessandra Silva","family":"Salgado","sequence":"additional","affiliation":[{"name":"Dr. Domingos A. Boldrini Children's Center for Hematologic Research, Boldrini Center, Campinas - SP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-7111","authenticated-orcid":false,"given":"Lucila Castanheira","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, University of S\u00e3o Paulo at Ribeir\u00e3o Preto College of Nursing, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1043454214563751"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PAED.2018.02.003"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000531"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001959"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1269736"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1269736"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15235549"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.25.18_suppl.9512"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_5_11_2","article-title":"Common Terminology criteria for adverse events (CTCAE).v.2.0","author":"National Cancer Institute","year":"1999","unstructured":"National Cancer Institute. Common Terminology criteria for adverse events (CTCAE).v.2.0. Cancer Therapy Evaluation Program (CTEP). 1999. https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/ctc_indexterms_7-99.pdf. Accessed 11 August 2018.","journal-title":"Cancer Therapy Evaluation Program (CTEP)"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000165"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05773-7"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000214"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05638-9"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.01.007"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.11.011"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251341522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748251341522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251341522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:23:42Z","timestamp":1777386222000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748251341522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":16,"alternative-id":["10.1177\/10732748251341522"],"URL":"https:\/\/doi.org\/10.1177\/10732748251341522","relation":{},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"article-number":"10732748251341522"}}