{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:05Z","timestamp":1787019065854,"version":"build-2736575974"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chengguan District Science and Technology Project of Lanzhou City","award":["2024SHFZ0018"],"award-info":[{"award-number":["2024SHFZ0018"]}]},{"name":"Gansu Provincial Traditional Chinese Medicine Research Project","award":["GZKG-2024-75"],"award-info":[{"award-number":["GZKG-2024-75"]}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["24JRRA333"],"award-info":[{"award-number":["24JRRA333"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cuiying Programme of Lanzhou University Second Hospital","award":["CY2021-BJ-A03"],"award-info":[{"award-number":["CY2021-BJ-A03"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The decline in mortality and increase in cure rates following distal gastrectomy have led to a growing focus on patient quality of life (QoL). This study aims to compare QoL outcomes between uncut Roux-en-Y (URY) and Billroth-II with Braun anastomosis (BIIB) reconstructions after totally laparoscopic distal gastrectomy (TLDG), and to identify the preferred surgical approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>From May 2017 to May 2019, a prospective randomized controlled trial (RCT) enrolled 101 gastric cancer patients undergoing TLDG, who were randomly allocated to either URY or BIIB reconstruction. The primary endpoint evaluated the superiority of URY in postoperative QoL at 24\u00a0months, as quantified by composite scores from the validated QLQ-C30 version 3.0 and QLQ-STO22 instruments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After TLDG, compared with BIIB, the URY group had lower EORTC QLQ-C 30 3.0 nausea and vomiting scores at 12 (3.6 (3.3) vs 8.3 (5.3)) and 24 (2.7 (3.4) vs 7.5 (4.2),\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) months; and fewer reflux symptoms in QLQ-STO 22 at 12 (6.7 (8.9) vs 13.7 (16.1)), and 24\u00a0months (4.7 (5.9) vs 12.5 (10.7),\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Meanwhile, patients who underwent URY also had better Gastrointestinal Symptom Rating Scale scores (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), and shorter frequency and duration of bile reflux at 3, 12, and 24\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01); shorter Bilitec monitoring for bilirubin aspiration at 3 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0032), 12 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0004), and 24\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.042); and lower rates of bile reflux gastritis at 3, 12, and 24\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). The mean pH of morning gastric fluid was obviously lower in the URY group at 1\u223c7\u00a0days postoperatively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>URY reconstruction after TLDG effectively reduced short-term bile reflux and improved patients\u2019 QoL compared to BIIB reconstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251384366","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T14:33:44Z","timestamp":1759502024000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparing Quality of Life for Billroth II With Braun Versus Uncut Roux-en-Y Reconstruction After Total Laparoscopic Distal Gastrectomy for Gastric Cancer: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-3606","authenticated-orcid":false,"given":"Xiaojun","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuya","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-5931","authenticated-orcid":false,"given":"Jianxing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luofei","family":"Chen","sequence":"additional","affiliation":[{"name":"First Department of General Surgery, Xianyang First People\u2019s Hospital, Xianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxiong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7391-8774","authenticated-orcid":false,"given":"Changjiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31288-5"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-011-2064-8"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.02.005"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31828c4a19"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3583-z"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0008"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106684"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i22.2832"},{"issue":"2","key":"e_1_3_9_12_2","first-page":"211","article-title":"Characteristics of distal partial gastrectomy patients with esophageal symptoms of duodenogastric reflux","volume":"90","author":"Sears RJ","year":"1995","unstructured":"Sears RJ, Champion GL, Richter JE. 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