{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:22:51Z","timestamp":1781299371444,"version":"3.54.1"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Anlotinib, a tyrosine kinase inhibitor, has demonstrated significant anti-tumor activity in hepatocellular carcinoma (HCC); nevertheless, the optimal combination therapy is still contested. Consequently, we synthesized the efficacy and safety of anlotinib in combination therapy for advanced HCC via meta-analysis, offering more extensive data for clinical application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, Web of Science, and Cochrane Library. The primary efficacy indicators included median overall survival (mOS), median progression-free survival (mPFS), overall response rate (ORR), and disease control rate (DCR). The relevant safety indicators were adverse events (AEs). We conducted a meta-analysis utilizing the STATA 14.0 statistical software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 14 studies involving 863 patients with HCC were included. The combination therapy with anlotinib showed an ORR of 33.8% (95% confidence intervals (CI): 26.8%-40.7%) and a DCR of 77.1% (95% CI: 70.1%-84.2%). The mPFS and mOS were 6.9\u00a0months (95% CI: 6.2-7.6) and 17.1\u00a0months (95% CI: 15.6-18.6), respectively. Common AEs associated with anlotinib combination therapy included liver function abnormalities 52.9% (95% CI: 37.7%-68.0%), hand-foot skin reaction 37.2% (95% CI: 26.2%-48.2%), and decreased appetite 32.0% (95% CI: 18.7%-45.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anlotinib-based combination therapy demonstrated promising efficacy with manageable safety in advanced HCC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251390032","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:00:06Z","timestamp":1760554806000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Efficacy and Safety of Anlotinib Combination Therapy for Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"32","author":[{"given":"Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Chengdu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Cui","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Neijiang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-8416","authenticated-orcid":false,"given":"Xinlin","family":"Yu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Chengdu 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