{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:50:40Z","timestamp":1791294640433,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tai\u2019an Science and Technology Development Guiding Project","award":["2022NS217"],"award-info":[{"award-number":["2022NS217"]}]},{"name":"Shandong Province Medical and Health Science and Technology Project","award":["202403040826"],"award-info":[{"award-number":["202403040826"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic lymphocytic leukemia (CLL) poses a growing challenge to public health. Tracking temporal trends in the burden of CLL provides critical evidence for guiding health strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using Global Burden of Disease 2021 data, we analyzed incidence, prevalence, deaths, disability-adjusted life years (DALYs), and the corresponding age-standardized rates (ASR), percentage changes, and estimated annual percentage changes (EAPC) for CLL from 1990-2021. Das Gupta\u2019s method was used to analyze the changes in CLL burden. The frontier analysis was employed to further investigate the relationship between CLL burden and social development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Global CLL incidence, death, and DALYs burden have decreased, while prevalence increased. High social development index (SDI) regions remained associated with a heavier burden but showed a downward trend, while other SDI regions showed a certain upward trend. The prevalence of CLL in East Asia increased significantly. The incidence and mortality rates of male were still higher than those of female. Smoking, high body mass index, and occupational exposure to benzene or formaldehyde remained key risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The global burden of CLL has decreased, but significant regional differences remain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251397071","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T17:31:38Z","timestamp":1762968698000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Global Burden of Chronic Lymphocytic Leukemia From 1990 to 2021"],"prefix":"10.1177","volume":"32","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"Tai\u2019an City Central Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Tai\u2019an City Central Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghong","family":"Du","sequence":"additional","affiliation":[{"name":"Tai\u2019an City Central Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Tai\u2019an City Central Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2718-0007","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Tai\u2019an City Central Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingliang","family":"Teng","sequence":"additional","affiliation":[{"name":"Tai\u2019an City Central Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2024.10.009"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00595-6"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.34119\/bjhrv6n5-325"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.019"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.740670"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a035220"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163735"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","unstructured":"Perez-Carretero C Gonzalez-Gascon YMI Rodriguez-Vicente AE et al. The evolving landscape of chronic lymphocytic leukemia on diagnosis prognosis and treatment. Diagnostics 2021;11(5):853. doi:10.3390\/diagnostics11050853","DOI":"10.3390\/diagnostics11050853"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S265284"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00862-z"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.837531"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002116"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.776847"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.04.011"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)30818-8"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.04480415"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14274-7"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-021-00973-6"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14412-1"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","unstructured":"Zygmunciak P Robak T Pula B. Treatment of double-refractory chronic lymphocytic Leukemia-An unmet clinical need. Int J Mol Sci 2024;25(3):1589. doi:10.3390\/ijms25031589","DOI":"10.3390\/ijms25031589"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-210905"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25595"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.898758"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.827785"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.072140"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.09.007"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0239-8"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.840616"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/0898264318824180"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.101378"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2013.e4"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-018-0213-7"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32040204"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-734541"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00423-4"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-023-00542-z"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1980"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-021-00973-6"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00456.x"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(25)01879-8"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw547"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.840616"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-211629"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1542317"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251397071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748251397071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251397071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:24:12Z","timestamp":1777386252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748251397071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":46,"alternative-id":["10.1177\/10732748251397071"],"URL":"https:\/\/doi.org\/10.1177\/10732748251397071","relation":{},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"10732748251397071"}}