{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:46:05Z","timestamp":1777484765944,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3L1611"],"award-info":[{"award-number":["CMRPG3L1611"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CORPG3N0151"],"award-info":[{"award-number":["CORPG3N0151"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 111-2314-B-182A-162"],"award-info":[{"award-number":["NSTC 111-2314-B-182A-162"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-182A-152"],"award-info":[{"award-number":["NSTC 112-2314-B-182A-152"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-182A-147"],"award-info":[{"award-number":["NSTC 113-2314-B-182A-147"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW112-TDU-B-222-124"],"award-info":[{"award-number":["MOHW112-TDU-B-222-124"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) predominantly affects older adults, whose treatment outcomes may be influenced by baseline health-related quality of life (HRQoL). This study aimed to identify predictors of poor preoperative HRQoL in older patients undergoing CRC surgery and to stratify them into risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed data on patients aged \u226565 years who underwent radical CRC surgery at a single medical center in Taiwan (2016-2018). Preoperative HRQoL was assessed using the EORTC QLQ-ELD14 questionnaire and a comprehensive geriatric assessment. Patients were stratified into high or low HRQoL groups based on the median QLQ-ELD14 sum score. Logistic regression identified independent predictors of poor HRQoL, and recursive partitioning analysis (RPA) was applied for risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 179 patients, the most distressing HRQoL domains were\n                      <jats:italic toggle=\"yes\">Burden of Disease<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Maintaining Purpose<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Worries about Others<\/jats:italic>\n                      . Independent predictors of poor HRQoL included female sex (adjusted odds ratio [OR] = 2.41,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.029), frailty (adjusted OR = 1.53,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.042), poor Eastern Cooperative Oncology Group (ECOG) performance status (adjusted OR = 2.19,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008), and lower educational attainment (adjusted OR = 0.23,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019). RPA identified five patient subgroups with distinct risk levels; frail female had the highest risk (71.4%), while fit patients with college education or higher had the lowest (9.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frailty, functional status, sex, and education level are key determinants of preoperative HRQoL in older patients with CRC. The RPA provides a simple tool to identify high-risk patients, allowing targeted preoperative interventions to optimize care and enhance surgical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251397079","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:41:03Z","timestamp":1762544463000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Preoperative Quality of Life in Older Patients With Colorectal Cancer in Taiwan: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Cheng-Chou","family":"Lai","sequence":"first","affiliation":[{"name":"Linkou Chang Gung Memorial Hospital"},{"name":"Chang Gung University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital"},{"name":"Chang Gung University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Huan","family":"Huang","sequence":"additional","affiliation":[{"name":"Linkou Chang Gung Memorial Hospital"},{"name":"Chang Gung University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Kai","family":"Liao","sequence":"additional","affiliation":[{"name":"Linkou Chang Gung Memorial Hospital"},{"name":"Chang Gung University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Wei","family":"Kou","sequence":"additional","affiliation":[{"name":"Chang Gung University"},{"name":"Chang Gung Memorial Hospital at Linkou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Chang Gung University"},{"name":"Chang Gung Memorial Hospital at Linkou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shin","family":"Hung","sequence":"additional","affiliation":[{"name":"Chang Gung University"},{"name":"Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chi","family":"Chou","sequence":"additional","affiliation":[{"name":"Chang Gung University"},{"name":"Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2024.102716"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02277-y"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-12-S1-S20"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2721-8"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-024-03040-z"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318214bce7"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2021.07.005"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59061129"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0348"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab343"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/07334648251321560"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02195"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2024.102069"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.17599"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2023.10.003"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2023.11.001"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008821826499"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.407"},{"key":"e_1_3_6_23_2","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1007\/978-1-4757-3027-2","volume-title":"Recursive Partitioning in the Health Sciences","author":"Zhang H","year":"1999","unstructured":"Zhang H, Singer B. 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