{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:01:30Z","timestamp":1781650890176,"version":"3.54.5"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Independent Research Funding of General Hospital of Northern Theater Command","award":["ZZKY2024018"],"award-info":[{"award-number":["ZZKY2024018"]}]},{"name":"Liaoning Provincial Science and Technology Plan Joint Plan","award":["2024JH2\/102600285"],"award-info":[{"award-number":["2024JH2\/102600285"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with liver cirrhosis are at a higher risk of developing non-hepatic cancers (NHC) than general population. Considering that NHC causes poor outcomes, it is necessary to explore the prevalence of NHC in such patients and identify its associated risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with a diagnosis of liver cirrhosis who were consecutively admitted to our hospital between January 1, 2010 and June 30, 2014 were retrospectively screened. They were divided into NHC, primary liver cancer (PLC), and non-cancer groups. After adjusting for age and sex, logistic regression analyses were performed to explore the risk factors of NHC in patients with cirrhosis. Adjusted odds ratios (aORs) with their 95% confidence intervals (CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 2509 patients with cirrhosis were included. Prevalence of NHC and PLC was 6.22% (156\/2509) and 22.20% (557\/2509), respectively. After adjusting for age and sex, the NHC group had a significantly higher proportion of history of smoking (aOR = 1.994; 95% CI = 1.231-3.231,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005), but lower proportions of history of encephalopathy (aOR = 0.344; 95% CI = 0.147- 0.804,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014) and history of heart disease (aOR = 0.300; 95% CI = 0.173-0.519,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) as compared to the non-cancer group. Hepatitis B virus infection (aOR = 0.863; 95% CI = 0.581-1.281,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.465), hepatitis C virus infection (aOR = 0.908; 95% CI = 0.503-1.642,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.750), and alcohol abuse alone (aOR = 1.254; 95% CI = 0.779-2.017,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.351) as the etiology of liver cirrhosis were not significantly associated with the risk of NHC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Smoking may be associated with a higher probability of NHC in patients with cirrhosis, but the probability of NHC may be compromised by encephalopathy or heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251403222","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T18:33:01Z","timestamp":1764441181000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Risk Factors for Non-Hepatic Cancers in Cirrhosis: A Cross-Sectional Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7051-621X","authenticated-orcid":false,"given":"Di","family":"Sun","sequence":"first","affiliation":[{"name":"General Hospital of Northern Theater Command"},{"name":"Dalian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4044-9158","authenticated-orcid":false,"given":"Liyan","family":"Dong","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"},{"name":"Northeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3908-7198","authenticated-orcid":false,"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"},{"name":"Dalian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-671X","authenticated-orcid":false,"given":"Yingchao","family":"Li","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"},{"name":"Dalian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7691-507X","authenticated-orcid":false,"given":"Junyuan","family":"Yin","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"},{"name":"Dalian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-9980","authenticated-orcid":false,"given":"Ran","family":"Wang","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-8947","authenticated-orcid":false,"given":"Deli","family":"Zou","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-6739","authenticated-orcid":false,"given":"Xingshun","family":"Qi","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450117666160613101413"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8"},{"issue":"5","key":"e_1_3_8_4_2","first-page":"372","article-title":"Diagnosis and treatment of rare complications of liver cirrhosis","volume":"28","author":"Gao ZQ","year":"2020","unstructured":"Gao ZQ, Ding HG. Diagnosis and treatment of rare complications of liver cirrhosis. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese J Hepatol. 2020;28(5):372-376.","journal-title":"Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese J Hepatol"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32434"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.01.033"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00365-y"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.10.014"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.06.007"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.406"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23754"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2918-5"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i45.12896"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282f4489f"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280404"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0578"},{"key":"e_1_3_8_17_2","volume-title":"Cancer: Disease Control Priorities","author":"Bray F","year":"2015","unstructured":"Bray F, Soerjomataram I. The changing global burden of cancer: transitions in human development and implications for cancer prevention and control. In: Gelband H, Jha P, Sankaranarayanan R, Horton S, eds. Cancer: Disease Control Priorities. 3rd ed. Washington (DC): The International Bank for Reconstruction and Development \/ The World Bank \u00a9 2015 International Bank for Reconstruction and Development \/ The World Bank; 2015.","edition":"3"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34395"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq763"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1432137"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3541365"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2023.130783"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnc.2022.04.004"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061370"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i14.1405"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-0036"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvad202"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.10.003"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-006-0111-z"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.12.1979"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh3083"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06605.x"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051019-102940"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300848"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)22007-6"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.023"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01200-4"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02041-2"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-023-00553-6"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.561420"},{"key":"e_1_3_8_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29995"},{"key":"e_1_3_8_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.477"},{"key":"e_1_3_8_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-495"},{"key":"e_1_3_8_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20608"},{"key":"e_1_3_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_3_8_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.07.019"},{"key":"e_1_3_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2011.07.010"},{"key":"e_1_3_8_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.08.023"},{"key":"e_1_3_8_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/34.6.894"},{"key":"e_1_3_8_51_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2173"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251403222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10732748251403222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10732748251403222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:24:14Z","timestamp":1777386254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10732748251403222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":50,"alternative-id":["10.1177\/10732748251403222"],"URL":"https:\/\/doi.org\/10.1177\/10732748251403222","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10732748251403222\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10732748251403222\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1073-2748","1526-2359"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1526-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"10732748251403222"}}