{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:06Z","timestamp":1787019066795,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Health, Ita"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      The somatostatin receptor (SSTR) standardized uptake value (SUVmax\n                      <jats:sub>sstr<\/jats:sub>\n                      ) obtained by [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]Ga-edotreotide positron emission tomography-computed tomography ([\n                      <jats:sup>68<\/jats:sup>\n                      Ga]Ga-SSTR PET\/CT) helps recognize patients with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who are at a high risk for adverse outcomes. This observational cohort study was conducted to verify whether the SSTR representative tumor volume (RTV\n                      <jats:sub>sstr<\/jats:sub>\n                      ) can provide incremental prognostic information over conventional PET\/CT parameters in patients with metastatic disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively evaluated patients (48% female) with metastatic GEP-NETs who underwent [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]Ga-SSTR PET\/CT between January 2022 and November 2023. The mean SUVmax\n                      <jats:sub>sstr<\/jats:sub>\n                      , mean RTV\n                      <jats:sub>sstr<\/jats:sub>\n                      (cm\n                      <jats:sup>3<\/jats:sup>\n                      ; 42% threshold), and total RTV\n                      <jats:sub>sstr<\/jats:sub>\n                      were recorded. Thereafter, patients were followed up for 22.9 (range: 8-42) months. The PET\/CT results were compared to the progression free survival (PFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients (59 \u00b1 5 years) were enrolled. Only the mean and total RTV\n                      <jats:sub>sstr<\/jats:sub>\n                      values were predictive in the multivariate analysis. Kaplan-Meier survival analysis for both the mean and total RTV\n                      <jats:sub>sstr<\/jats:sub>\n                      demonstrated a significantly better PFS in patients presenting with lower than greater values (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007, respectively; log-rank test). SUVmax\n                      <jats:sub>sstr<\/jats:sub>\n                      was not appropriate for predicting PFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The mean or total RTV\n                      <jats:sub>sstr<\/jats:sub>\n                      represents a valuable volumetric parameter able to predict outcomes in patients with GEP-NETs that are metastatic at onset. The degree of the SSTR representative tumor burden, rather than the maximal SSTR representation at single voxel, has a predominant value for influencing the response to therapy in this cohort.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748251413808","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T04:13:00Z","timestamp":1769141580000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ga-68-Edotreotide PET\/CT SSTR Total Tumor Volume as a Predictor of Outcome in Patients With Metastatic Gastroenteropancreatic Neuroendocrine Tumors"],"prefix":"10.1177","volume":"33","author":[{"given":"Rosj","family":"Gallicchio","sequence":"first","affiliation":[{"name":"Referral Cancer Center of Basilicata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarita","family":"Milella","sequence":"additional","affiliation":[{"name":"Referral Cancer Center of Basilicata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giordano","sequence":"additional","affiliation":[{"name":"Referral Cancer Center of Basilicata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Cives","sequence":"additional","affiliation":[{"name":"University of Bari \u201cAldo Moro\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Storto","sequence":"additional","affiliation":[{"name":"Referral Cancer Center of Basilicata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nardelli","sequence":"additional","affiliation":[{"name":"Institute of Biostructures and Bioimages CNR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-1401","authenticated-orcid":false,"given":"Giovanni","family":"Calice","sequence":"additional","affiliation":[{"name":"Referral Cancer Center of Basilicata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Landriscina","sequence":"additional","affiliation":[{"name":"University of Foggia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-5598","authenticated-orcid":false,"given":"Giovanni","family":"Storto","sequence":"additional","affiliation":[{"name":"Referral Cancer Center of Basilicata"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21493"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v12.i8.791"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn351"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.11.2222"},{"key":"e_1_3_8_6_2","volume-title":"WHO Classification of Tumors of Endocrine Organs","author":"Lloyd RV","year":"2017","unstructured":"Lloyd RV, Osamura YR, Kloppel G, Rosai J. 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