{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:07:28Z","timestamp":1792523248476,"version":"4.5.0"},"reference-count":71,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["530744"],"award-info":[{"award-number":["530744"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) is a well-established cause of cervical cancer and is increasingly recognized as an important risk factor for non-cervical cancers, including oropharyngeal, anal, vulvar, vaginal, and penile cancers. This study assessed temporal trends in the incidence of HPV-related cervical and non-cervical cancers in Canada and the Netherlands by sex assigned at birth and cancer type using population-based registry data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a registry-based observational study, in which we analyzed retrospective data from the Canadian Cancer Registry (1992-2022) and the Netherlands Cancer Registry (2000-2019) for HPV-related cancers. Age-standardized incidence rates, annual percentage changes (APC), and average annual percentage changes (AAPC), with corresponding 95% confidence intervals (95% CI), were estimated using Joinpoint regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Canada, cervical cancer incidence rate generally declined since 1992 but has increased by 1.1% (0.5, 2.7) annually between 2013 and 2022. In the Netherlands, cervical cancer rates remained stable until 2015, followed by a 5.1% (1.9, 11.5) annual increase between 2015 and 2019. Non-cervical HPV-related cancers generally increased in both countries. In Canada, from 1992 to 2022, incidence rates increased for oropharyngeal (AAPC: 2.0% [1.6, 2.4]), anal (1.7% [1.3, 2.2]), and vulvovaginal (1.9% [1.6, 2.3]) cancers. In the Netherlands, from 2000 to 2019, incidence rates increased for anal (5.3% [4.2, 6.8]), vulvar (3.0% [2.2, 4.0]), penile cancers (2.8% [1.7, 4.0]), and oropharyngeal cancer (0.7% [0.1, 1.2]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In general, we observed similar trends in both countries: that the incidence of HPV-related cervical and non-cervical cancers in Canada and the Netherlands is rising. These findings highlight the need to expand HPV vaccination programs, optimize HPV-related cancer screening programs, and enhance public health initiatives for the prevention and early detection of non-cervical HPV-related cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748261445046","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:32:13Z","timestamp":1776763933000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Trends in the Incidence of Human Papillomavirus-Related Cancers in Canada and the Netherlands"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4045-1688","authenticated-orcid":false,"given":"Emily","family":"Niu","sequence":"first","affiliation":[{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6754-6153","authenticated-orcid":false,"given":"Ioana A.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Olthof","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Center"},{"name":"Erasmus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-0452","authenticated-orcid":false,"given":"Inge M. 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