{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:08:06Z","timestamp":1778940486469,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fujian Cancer Hospital High-Level Talent Training Program","award":["2023YNG09"],"award-info":[{"award-number":["2023YNG09"]}]},{"name":"Joint Funds for the innovation of science and Technology, Fujian province","award":["2023Y9449"],"award-info":[{"award-number":["2023Y9449"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011099"],"award-info":[{"award-number":["2024J011099"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J011273"],"award-info":[{"award-number":["2023J011273"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vulvar Paget\u2019s disease (VPD) is a rare condition, and a comprehensive analysis of its clinical and pathological characteristics, treatment approaches, and prognosis has not yet been conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective population-based cohort study using publicly available, de-identified data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients diagnosed with VPD between 2004 and 2021were included. Kaplan-Meier and Cox models assessed impacts on overall and cancer-specific survival. Propensity score matching (PSM) balanced surgical and non-surgical groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1,778 patients with VPD were included. Most patients were women aged \u226550 years (96.5%) and of White race (81.7%). The labium majus was the most commonly specified tumor site (203\/1,778, 11.4%), although most cases were recorded as vulva, NOS. A total of 1,374 patients underwent surgical treatment. After PSM, surgery remained associated with improved survival. A generally similar trend was observed across subgroups, although not all subgroup comparisons reached statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on the SEER database, this study found that surgery was beneficial for improving the prognosis of VPD patients, especially for those who were elderly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748261450261","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:04:42Z","timestamp":1778774682000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival and Treatment Patterns in Vulvar Paget\u2019s Disease: Evidence From SEER"],"prefix":"10.1177","volume":"33","author":[{"given":"Lele","family":"Chang","sequence":"first","affiliation":[{"name":"Fujian Cancer Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Kang","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuibo","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5916-9828","authenticated-orcid":false,"given":"Qin","family":"Xu","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital"},{"name":"Fujian Cancer Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","unstructured":"Edey KA Allan E Fau - Murdoch JB et al. Interventions for the treatment of Paget\u2019s disease of the vulva. The Cochrane Database of Systematic Reviews. 2013;CD009245. DOI: 10.1002\/14651858.cd009245","DOI":"10.1002\/14651858.cd009245"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000080"},{"key":"e_1_3_8_4_2","unstructured":"Phyo AK Mun KS Kwan KC Ann CC Kuppusamy S. Genitourinary extramammary Paget's disease: review and outcome in a multidisciplinary setting. Int J Clin Exp Pathol. 2020;13(9): 2369-2376."},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","unstructured":"van der Linden M Oonk MHM van Doorn HC et al. Vulvar Paget disease: A national retrospective cohort study. J Am Acad Dermatol. 81(4): 956-962. DOI: 10.1016\/j.jaad.2018.11.016","DOI":"10.1016\/j.jaad.2018.11.016"},{"key":"e_1_3_8_6_2","doi-asserted-by":"crossref","unstructured":"Ishizuki S Nakamura YA-O. Extramammary Paget's Disease: Diagnosis Pathogenesis and Treatment with Focus on Recent Developments. 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