{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:55:01Z","timestamp":1790996101006,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Foundation of Jiangxi Province","award":["20252BAC220049"],"award-info":[{"award-number":["20252BAC220049"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["20252BAC240440"],"award-info":[{"award-number":["20252BAC240440"]}]},{"name":"Ganzhou Municipal Science and Technology Project","award":["2025ZSFCE0183"],"award-info":[{"award-number":["2025ZSFCE0183"]}]},{"name":"Ganzhou Municipal Science and Technology Project","award":["GZ2024YLJ040"],"award-info":[{"award-number":["GZ2024YLJ040"]}]},{"name":"the funds of the Medical Leading Discipline of Ganzhou City"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Various industrial pollutants have been implicated in tumorigenesis. However, the cancer risk associated with microplastics, a pervasive environmental pollutant, remains poorly understood. This study aimed to evaluate the association between basin-level environmental microplastic contamination and cancer incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this secondary analysis of a prospective UK Biobank cohort, 378,985 participants were linked to basin-level river microplastic measurements using residential coordinates. The 2019 measurements were treated as an ecological proxy for regional environmental microplastic contamination. Participants were categorized into low, moderate, or high exposure groups, and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a mean follow-up of 12.39 years, 37,322 participants developed at least one of the 24 cancer outcomes. Compared with participants in low-exposure basins, participants in high-exposure basins had increased risks of liver cancer (HR, 1.252; 95% CI, 1.031-1.520), colon cancer (HR, 1.167; 95% CI, 1.088-1.252), and lung cancer (HR, 1.198; 95% CI, 1.095-1.309). These estimates represent modest relative increases and should be interpreted alongside absolute event counts and confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher basin-level river microplastic contamination was associated with modestly higher incidence of selected digestive and respiratory cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient or Public Contribution<\/jats:title>\n                    <jats:p>This study was a secondary analysis of de-identified data from the prospective UK Biobank cohort. Patients, service users, and members of the public were not directly involved in the design, analysis, interpretation, or preparation of this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748261493417","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:01:36Z","timestamp":1790672496000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Microplastic Pollution and Risk of Cancer: A Prospective Study Based on UK Biobank"],"prefix":"10.1177","volume":"33","author":[{"given":"Simeng","family":"You","sequence":"first","affiliation":[{"name":"Ganzhou Hospital-Nanfang Hospital"},{"name":"Southern Medical University (Ganzhou People\u2019s Hospital)"},{"name":"Ganzhou People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of 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