{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:49:25Z","timestamp":1777484965277,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>T-cell prolymphocytic leukemia (T-PLL) is a post-thymic T-cell malignancy with aggressive clinical course. Although T-PLL has been referred to under different designations, it is a distinct clinico-biological entity and should be distinguished from other T-cell disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The literature on T-PLL is reviewed. Experience on the clinical and laboratory features, differential diagnosis, and therapy on a large series of T-PLL patients is presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>T-PLL affects adults and occurs more frequently in men. The principal disease characteristics are organomegaly, skin lesions, and a raised lymphocyte count. Immunological markers show a post-thymic T-cell phenotype (TdT\u2013 CD2+ CD5+ CD3\u00b1) with strong expression of CD7. A CD4+ CD8\u2013 phenotype is seen in two thirds of cases. CD4 and CD8 are coexpressed in 25%, and a CD4\u2013 CD8+ phenotype is rare. Cytogenetics show a recurrent abnormality inv(14)(q11;q32) that is always associated to other aberrations (particularly iso8q or trisomy 8). Differential diagnosis between T-PLL and other T-cell malignancies is based on a constellation of clinical and laboratory features. Generally, T-PLL patients are refractory to the therapy used in lymphoid disorders. Median survival is short but is improving with the use of 2'-deoxycoformycin and the humanized monoclonal antibody, anti-CDw52 (Campath-1H).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>T-PLL is a distinct T-cell disorder with characteristic clinical and laboratory features and a poor prognosis. A precise diagnosis of this disease is important in determining patient management and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/107327489800500102","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T07:14:49Z","timestamp":1504077289000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["T-cell Prolymphocytic Leukemia"],"prefix":"10.1177","volume":"5","author":[{"given":"Estella","family":"Matutes","sequence":"first","affiliation":[{"name":"Royal Marsden Hospital and Institute of Cancer Research, London, England."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"bibr1-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93135-8"},{"key":"bibr2-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/77.5.643"},{"key":"bibr3-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831201)52:11<2049::AID-CNCR2820521114>3.0.CO;2-O"},{"key":"bibr4-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830160412"},{"key":"bibr5-107327489800500102","first-page":"127","volume":"65","author":"Simpkins H.","year":"1985","journal-title":"Blood."},{"key":"bibr6-107327489800500102","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1182\/blood.V58.5.1047.1047","volume":"58","author":"Levine A.M.","year":"1981","journal-title":"Blood."},{"key":"bibr7-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07579.x"},{"key":"bibr8-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.4.926.926"},{"key":"bibr9-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.12.3269.3269"},{"key":"bibr10-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.6.567"},{"key":"bibr11-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600617"},{"key":"bibr12-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400725"},{"key":"bibr13-107327489800500102","first-page":"454","volume":"34","author":"Cervantes J.","year":"1986","journal-title":"Clin Res."},{"key":"bibr14-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.8.3520.bloodjournal8783520"},{"key":"bibr15-107327489800500102","first-page":"79","volume":"3","author":"Nieto L.H.","year":"1989","journal-title":"Hematol Pathol."},{"key":"bibr16-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05023.x"},{"key":"bibr17-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1720.x"},{"key":"bibr18-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02352.x"},{"key":"bibr19-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.2.154"},{"key":"bibr21-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"bibr22-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910270309"},{"key":"bibr23-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.2.423.bloodjournal872423"},{"key":"bibr24-107327489800500102","first-page":"379","volume":"12","author":"Thick J.","year":"1996","journal-title":"Oncogene."},{"key":"bibr25-107327489800500102","first-page":"1694","volume":"9","author":"Maljaie S.H.","year":"1995","journal-title":"Leukemia."},{"key":"bibr26-107327489800500102","first-page":"262","volume":"4","author":"Matutes E.","year":"1990","journal-title":"Leukemia."},{"key":"bibr27-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.9702605.x"},{"key":"bibr28-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb02809.x"},{"key":"bibr29-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07499.x"},{"key":"bibr30-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.12.2588"},{"key":"bibr31-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2667"},{"key":"bibr32-107327489800500102","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3213138.x"}],"container-title":["Cancer Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107327489800500102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107327489800500102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:24:52Z","timestamp":1777386292000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/107327489800500102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1177\/107327489800500102"],"URL":"https:\/\/doi.org\/10.1177\/107327489800500102","relation":{},"ISSN":["1073-2748","1073-2748"],"issn-type":[{"value":"1073-2748","type":"print"},{"value":"1073-2748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}