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Simultaneous orchestration of distinct cells and interconnected neural circuits relies on hundreds, if not thousands, of unique molecular interactions. Even single molecule dysfunctions can be disrupting to neural circuit activity, leading to neurological pathology. Here, we sample our current understanding of how molecular aberrations lead to disruptions in networks using three neurological pathologies as exemplars: epilepsy, traumatic brain injury (TBI), and Alzheimer\u2019s disease (AD). Epilepsy provides a window into how total destabilization of network balance can occur. TBI is an abrupt physical disruption that manifests in both acute and chronic neurological deficits. Last, in AD progressive cell loss leads to devastating cognitive consequences. Interestingly, all three of these neurological diseases are interrelated. The goal of this review, therefore, is to identify molecular changes that may lead to network dysfunction, elaborate on how altered network activity and circuit structure can contribute to neurological disease, and suggest common threads that may lie at the heart of molecular circuit dysfunction.<\/jats:p>","DOI":"10.1177\/1073858415585108","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T21:51:13Z","timestamp":1430949073000},"page":"295-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["From Molecular Circuit Dysfunction to Disease"],"prefix":"10.1177","volume":"22","author":[{"given":"Chris G.","family":"Dulla","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Coulter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neuroscience, University of Pennsylvania Perleman School of Medicine, Philadelphia, PA, USA"},{"name":"Division of Neurology and the Research Institute of Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jokubas","family":"Ziburkus","sequence":"additional","affiliation":[{"name":"Department of Biology and Biochemistry, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"bibr1-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2433"},{"key":"bibr2-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.01.024"},{"key":"bibr3-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"bibr4-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90424-7"},{"key":"bibr5-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2000.0458"},{"key":"bibr6-1073858415585108","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00277"},{"key":"bibr7-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600301"},{"key":"bibr8-1073858415585108","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2194"},{"key":"bibr9-1073858415585108","doi-asserted-by":"crossref","unstructured":"Bedner P, Dupper A, Huttmann K, Muller J, Herde MK, Dublin P, and others. 2015. 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