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This detrimental effect emerges from glutamate binding to glutamate receptors, including \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, N-methyl-d-aspartate receptors, kainate receptors, and GluD receptors. Thus, excitotoxicity could be prevented by targeting glutamate receptors and their downstream signaling pathways. However, almost all the glutamate receptor antagonists failed to attenuate excitotoxicity in human patients, mainly due to the limited understanding of the underlying mechanisms regulating excitotoxicity. Transient receptor potential (TRP) channels serve as ancient cellular sensors capable of detecting and responding to both external and internal stimuli. The study of human TRP channels has flourished in recent decades since the initial discovery of mammalian TRP in 1995. These channels have been found to play pivotal roles in numerous pathologic conditions, including excitotoxicity. In this review, our focus centers on exploring the intricate interactions between TRP channels and glutamate receptors in excitotoxicity.<\/jats:p>","DOI":"10.1177\/10738584241246530","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T05:43:13Z","timestamp":1714369393000},"page":"80-97","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["TRP Channels in Excitotoxicity"],"prefix":"10.1177","volume":"31","author":[{"given":"Pengyu","family":"Zong","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA"},{"name":"Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Legere","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA"},{"name":"The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-091X","authenticated-orcid":false,"given":"Lixia","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"bibr1-10738584241246530","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404272966"},{"key":"bibr2-10738584241246530","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00051"},{"key":"bibr3-10738584241246530","doi-asserted-by":"crossref","unstructured":"Belrose JC, Jackson MF. 2018. TRPM2: a candidate therapeutic target for treating neurological diseases. 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