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Although schemas have long been central to theories of memory and cognition, their neural implementation is only now becoming accessible through advances in large-scale neural recordings, population-level analysis methods, and precise causal circuit tools. Here we review the emerging systems neuroscience of schemas, focusing on animal models where mechanistic dissection is feasible. We argue that schema formation, use, and updating are not discrete processes but reflect a continuous adaptive interplay between the strength of prior knowledge and the degree to which new information aligns with it. At the neural level, schemas appear to be encoded as structured low-dimensional population geometries distributed across hippocampal-prefrontal circuits, with distinct but interacting contributions from orbitofrontal cortex, medial prefrontal cortex, anterior cingulate cortex, and hippocampus. These representations actively shape perception, guide behavior, and reorganize when the environment demands it.<\/jats:p>","DOI":"10.1177\/10738584261489262","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T05:54:27Z","timestamp":1792562067000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Schematic Brain: The Neurophysiology of Behavioral Schemas"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-5980","authenticated-orcid":false,"given":"Ido","family":"Maor","sequence":"first","affiliation":[{"name":"Intramural Research Program of the National Institute on Drug Abuse, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zong","sequence":"additional","affiliation":[{"name":"Intramural Research Program of the National Institute on Drug Abuse, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-5607","authenticated-orcid":false,"given":"Dilara","family":"Gostolupce","sequence":"additional","affiliation":[{"name":"Intramural Research Program of the National Institute on Drug Abuse, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-0701","authenticated-orcid":false,"given":"Geoffrey","family":"Schoenbaum","sequence":"additional","affiliation":[{"name":"Intramural Research Program of the National Institute on Drug Abuse, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"crossref","unstructured":"Akam T et al. 2021. 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