{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:17:59Z","timestamp":1777529879788,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>Background: CVT-510, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside, is a selective A,-adenosine receptor agonist with potential potent antiarrhythmic effects in tachycardias involving the atrioventricular (AV) node. This study, the first in humans, was designed to determine the effects of CVT-5 10 on AV nodal conduction and hemodynamics.<\/jats:p>\n                  <jats:p>Methods and Results: Patients in sinus rhythm with normal AV nodal function at electrophysiologic study (n = 32) received a single intravenous bolus of CVT-5 10. AH and HV intervals were measured during sinus rhythm and during atrial pacing at 1, 5, 10, 15, 20, 30, 45, and 60 minutes after the bolus. Increasing doses of CVT-510 (0.3 to 10 pg\/kg) caused a dosedependent increase in the AH interval. At 1 minute, a dose of 10,ug\/kg increased the AH interval during sinus rhythm from 93 \u00b1 23 msec to 114 \u00b1 37 msec, p = 0.01 and from 114 \u00b1 31 msec to 146 \u00b1 44 msec during atrial pacing at 600 msec, p = 0.003). The AH interval returned to baseline by 20 minutes. CVT-510 at doses of 0.3 to 10,ug\/kg had no effect on sinus rate, HV interval, or systemic blood pressure, and was not associated with serious adverse effects. At doses of 15 and 30 pg\/kg, CVT-510 produced transient second\/third degree AV heart block in all four patients treated. One of these patients also had a prolonged sedative effect that was reversed with aminophylline.<\/jats:p>\n                  <jats:p>\n                    Conclusions: CVT-510 promptly prolongs AV nodal conduction and does not affect sinus rate or blood pressure. Selective stimulation of the A,-adenosine receptor by CVT-510 may be useful for immediate control of heart rate in atrial fibrillation\/flutter and to convert paroxysmal supraventricular tachycardia to sinus rhythm, while avoiding vasodilatation mediated by the A\n                    <jats:sub>2<\/jats:sub>\n                    -adenosine receptor, as well as the vasodepressor and negative inotropic effects associated with 3-adrenergic receptor blockade and\/or calcium channel blockers.\n                  <\/jats:p>","DOI":"10.1177\/107424840100600304","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:24:09Z","timestamp":1182461049000},"page":"237-245","source":"Crossref","is-referenced-by-count":30,"title":["Electrophysiologic Effects of a Novel Selective Adenosine A1 Agonist (CVT-510) on Atrioventricular Nodal Conduction in Humans"],"prefix":"10.1177","volume":"6","author":[{"given":"Bruce B.","family":"Lerman","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York Hospital-Cornell University Medical College, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Ellenbogen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Medical College of Virginia, Richmond, VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Kadish","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Northwestern University Medical Center, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Platia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Washington Hospital Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Markowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suneet","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Slotwiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Scheiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York Hospital-Cornell University Medical College, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"Belardinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Jerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revati","family":"Shreeniwas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Wolff","sequence":"additional","affiliation":[{"name":"CV Therapeutics, Inc. Palo Alto, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1499"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.4.427"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.5.7896004"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00256-7"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702287"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90517-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-4-503"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90353-E"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(97)70319-6"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90141-0"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91013-V"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90076-3"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90885-O"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90580-0"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80525-6"},{"key":"atypb16","first-page":"1238","volume":"17","author":"Phillips BG","year":"1997","journal-title":"Pharmacology"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70031-6"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.8.1034"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-6-199709150-00001"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1995.tb01031.x"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(96)00044-4"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107424840100600304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107424840100600304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:40:59Z","timestamp":1777394459000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/107424840100600304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1177\/107424840100600304"],"URL":"https:\/\/doi.org\/10.1177\/107424840100600304","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}