{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:11Z","timestamp":1787019071354,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>Objective: We sought to assess the efficacy and safety of amiodarone for restoration and maintenance of sinus rhythm in patients with chronic atrial fibrillation in a prospective, randomized, double blind trial.<\/jats:p>\n                  <jats:p>Background: Restoration and preservation of sinus rhythm is difficult in patients with chronic atrial fibrillation. The efficacy of oral amiodarone has not been conclusively established.<\/jats:p>\n                  <jats:p>Methods: Ninety-five patients with chronic atrial fibrillation, lasting an average of 35.6 months, were randomized to either amiodarone (600 mg\/d) (47 patients) or placebo (48 patients) during four weeks. Nonresponders underwent electric cardioversion, and those who reverted continued with amiodarone (200 mg\/d) or placebo. End-points were successful cardioversion and sinus rhythm maintenance.<\/jats:p>\n                  <jats:p>Results: Sixteen patients (34.04%) in the amiodarone group reverted within 27.28 \u00b1 8.85 days in comparison with 0% in the placebo group (P &lt; 0.000009). The conversion rate rose to 51.72% in patients with chronic atrial fibrillation lasting less than 12 months. Twenty-eight patients in the amiodarone group and 39 in the placebo group underwent electric cardioversion, which was successful in 19 patients (67.8%) of the amiodarone group and in 15 (38.46%) of the placebo group (P = 0.017). Altogether, conversion was obtained in 79.54% of the amiodarone group patients and in 38.46% of the placebo group patients (P &lt; 0.0001). During follow-up, atrial fibrillation relapsed in 13 (37.14%) of 35 patients of the amiodarone group within 8.84 + 8.57 months and in 12 (80%; P = 0.009) of 15 patients of the placebo group within 2.74 \u00b1 3.41 months.<\/jats:p>\n                  <jats:p>Conclusions: Oral amiodarone restored sinus rhythm in one third of patients with chronic atrial fibrillation, increased the success rate of electric cardioversion, decreased the number of relapses and delayed their occurrence.<\/jats:p>","DOI":"10.1177\/107424840100600403","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:24:09Z","timestamp":1182461049000},"page":"341-350","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy of Amiodarone for the Termination of Chronic Atrial Fibrillation and Maintenance of Normal Sinus Rhythm: A Prospective, Multicenter, Randomized, Controlled, Double Blind Trial"],"prefix":"10.1177","volume":"6","author":[{"given":"Jorge","family":"Galperin","sequence":"first","affiliation":[{"name":"GEFACA Investigators-GEMA GROUP, Buenos Aires, Argentina; Hospital Durand, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo V.","family":"Elizari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Chiale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remberto Torres","family":"Molina","sequence":"additional","affiliation":[{"name":"GEFACA Investigators-GEMA GROUP, Buenos Aires, Argentina; Hospital Ramos Mejia, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauil","family":"Ledesma","sequence":"additional","affiliation":[{"name":"GEFACA Investigators-GEMA GROUP, Buenos Aires, Argentina; Instituto del Corazon, Cordoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel O.","family":"Scapin","sequence":"additional","affiliation":[{"name":"GEFACA Investigators-GEMA GROUP, Buenos Aires, Argentina; G.E.M.A. Grupo de Estudios Multicentricos Argentinos, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Vaizquez","family":"Blanco","sequence":"additional","affiliation":[{"name":"GEFACA Investigators-GEMA GROUP, Buenos Aires, Argentina; 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