{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:18:36Z","timestamp":1777529916566,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>Background: Beta-Cyclodextrin tetradecasulfate binds fibroblast growth factors and possesses anticoagulant properties. This study was designed to assess the separate and combined effects of local intramural delivery and intravenous administration of \u03b2-cyclodextrin tetradecasulfate on neointimal formation and arterial damage following angioplasty.<\/jats:p>\n                  <jats:p>\n                    Methods and Results: Fifty-two pigs randomized into four groups underwent coronary artery angioplasty: 1) control, 2) continuous intravenous infusion of 100 mg\/kg\/d of \u03b2-cyclodextrin tetradecasulfate, 3) intramural delivery of 1250 mg \u03b2-cyclodextrin tetradecasulfate, 4) intramural delivery of 1250 mg \u03b2-cyclodextrin tetradecasulfate followed by continuous intravenous infusion of 100 mg\/kg\/d. Fourteen days after injury, morphometric analysis revealed that arteries randomized to the intravenous \u03b2-cyclodextrin tetradecasulfate groups had a decreased normalized neointima area: control, 3.03 \u00b1 0.75 mm\n                    <jats:sup>2<\/jats:sup>\n                    ; intravenous, 1.67 \u00b1 0.73 mm\n                    <jats:sup>2<\/jats:sup>\n                    (40% decrease; P &lt; 10-7); intravenous plus local, 1.95 \u00b1 0.76 mm\n                    <jats:sup>2<\/jats:sup>\n                    (30% decrease; P &lt; 10-5). There was no difference in neointimal response following local \u03b2-cyclodextrin tetradecasulfate delivery only (2.82 \u00b1 1.14 mm\n                    <jats:sup>2<\/jats:sup>\n                    ). Coronary arterial damage, defined as aneurysm, dissection, adventitial rupture, and retromedial hematoma was similar in all groups (12% in control and local groups, 10% in the intravenous group, 14% in the intravenous plus local; NS). Bleeding complications were more frequent in the intravenous and intravenous plus local groups compared to the local and control groups (23%vs 7.6% and 0%, respectively; P &lt; 0.05).\n                  <\/jats:p>\n                  <jats:p>Conclusions: Continuous intravenous administration of \u03b2-cyclodextrin tetradecasulfate substantially reduced intimal hyperplasia, while intramural delivery had no effect, indicating that a single bolus of \u03b2-cyclodextrin tetradecasulfate did not reduce intimal hyperplasia. There was no additive effect of local intramural delivery of \u03b2-cyclodextrin tetradecasulfate. However, local delivery of \u03b2-cyclodextrin tetradecasulfate induced less bleeding complications and did not lead to additional arterial injury, indicating that local delivery of an anticoagulant does not cause additional arterial injury.<\/jats:p>","DOI":"10.1177\/107424840300800i108","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:24:09Z","timestamp":1182461049000},"page":"53-60","source":"Crossref","is-referenced-by-count":2,"title":["Separate and Combined Effects of Local and Continuous Intravenous Administration of \u03b2-Cyclodextrin Tetradecasulfate on Intimal Hyperplasia after Angioplasty in Porcine Coronary Arteries"],"prefix":"10.1177","volume":"8","author":[{"given":"Nicolas F.","family":"Meneveau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce D.","family":"Klugherz","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Cardiovascular Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brahim","family":"Chaquor","sequence":"additional","affiliation":[{"name":"Anatomy and Histology, School of Dental Medicine, University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Golden","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine M.","family":"Jouille","sequence":"additional","affiliation":[{"name":"Bioengineering of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Macarek","sequence":"additional","affiliation":[{"name":"Anatomy and Histology, School of Dental Medicine, University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul B.","family":"Weisz","sequence":"additional","affiliation":[{"name":"Bioengineering of the University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Wilensky","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Cardiovascular Division; Laboratory for Experimental Interventional Cardiology, 3400 Spruce Street, 9 Gates, Hospital of the University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118322"},{"key":"atypb2","first-page":"948","volume":"273","author":"Okada SS","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.6.924"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200205000-00009"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90263-9"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1126\/science.2467380"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90531-D"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.2041"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.106614"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.26"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.8.1542"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.3.1262"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00345-2"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.1.154"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.433"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90103-5"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199311000-00011"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90482-W"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.638"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.1003"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90170-2"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1518"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(199905)47:1<102::AID-CCD22>3.0.CO;2-G"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1177\/107424849900400306"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1177\/107424849900400205"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00614-8"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.12.1453"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1038\/81176"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107424840300800i108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107424840300800i108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:41:10Z","timestamp":1777394470000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/107424840300800i108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1177\/107424840300800i108"],"URL":"https:\/\/doi.org\/10.1177\/107424840300800i108","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}