{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:45:29Z","timestamp":1792658729920,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T00:00:00Z","timestamp":1272585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>Cyclosporine A (CsA) has been shown to protect against myocardial ischemia and reperfusion (I\/R) injury in small animal models. The aim of the current study was to evaluate the effects of CsA on myocardial I\/R injury in a porcine model. Pigs were randomized between CsA (10mg\/kg; n = 12) or placebo (n = 15) and anesthetized with either isoflurane (phase I) or pentobarbital (phase II). By catheterization, the left descending coronary artery was occluded for 45 minutes, followed by reperfusion for 2 hours. Hearts were stained to quantify area at risk (AAR) and infarct size (IS). Myocardial biopsies were obtained for terminal dUTP nick end labeling and immunoblot analysis of proapoptotic proteins (apoptosis-inducing factor [AIF], BCL2\/adenovirus E1B 19-kd interacting protein 3 [BNIP-3], and active caspase-3). Cyclosporine A did not reduce IS\/AAR compared with placebo (49% vs 41%, respectively; P = .21). Pigs anesthetized with isoflurane had lower IS\/AAR than pigs anesthetized with pentobarbital (39% vs 51%, respectively; P = .03). This reduction in IS\/AAR seemed to be attenuated by CsA. Apoptosis-inducing factor protein expression was higher after CsA administration than after placebo (P = .02). Thus, CsA did not protect against I\/R injury in this porcine model. The data suggest a possible deleterious interaction of CsA and isoflurane.<\/jats:p>","DOI":"10.1177\/1074248410362074","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T19:23:15Z","timestamp":1272655395000},"page":"182-189","source":"Crossref","is-referenced-by-count":50,"title":["Cyclosporine Does Not Reduce Myocardial Infarct Size in a Porcine Ischemia-Reperfusion Model"],"prefix":"10.1177","volume":"15","author":[{"given":"Lars O.","family":"Karlsson","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden, Department of Molecular and Clinical Medicine, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex-Xianghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, University of 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