{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:30:43Z","timestamp":1790865043601,"version":"4.1.0"},"reference-count":71,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T00:00:00Z","timestamp":1286755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>Objective: Coronary artery diseases including myocardial ischemia (MI) remain one of the leading causes of death worldwide. This study was designed to compare the protective effect of L-arginine versus aspirin from the biochemical changes associated with MI injury. Experimental design: Four groups of male New Zealand white rabbits were investigated. Normal group (n = 8) rabbits were fed standard chow pellets, untreated MI group (n = 16), where hypercholesterolemia was induced by feeding the animals with a diet containing 2% cholesterol for 28 days, L-arginine group (n = 12) rabbits were fed a 2% cholesterol-enriched diet in conjunction with L-arginine (2.25 g %) in drinking water for 28 days, and aspirin group (n = 12) rabbits were fed 2% cholesterol-enriched diet in conjunction with aspirin administered orally (0.7 mg\/kg per d) for 28 days. After 28 days, MI was induced in all groups, except the normal group, by a single subcutaneous (sc) injection of isoproterenol hydrochloride (0.2 mg\/kg body weight [bw]). Animals were sacrificed 6 hours later. Results: Our results showed that L-arginine was more effective than aspirin in reducing platelet aggregation, reducing low-density lipoprotein (LDL) oxidizability, preventing aortic intimal thickening, and maintaining histological architecture of the myocardium. Both drugs, however, had similar positive effects on plasma fibrinogen levels and on the prevention of myocardial release of cardiac troponin I and creatine kinase-MB. The effect on hypercholesterolemia was insignificant for both drugs. Aspirin was more effective than L-arginine in prolonging prothrombin time. Conclusion: L-arginine supplementation represents a potentially novel nutritional strategy for preventing and treating coronary artery diseases especially in cases of aspirin resistance and\/or hypersensitivity.<\/jats:p>","DOI":"10.1177\/1074248410378506","type":"journal-article","created":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:47:33Z","timestamp":1286844453000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective Effect of L-Arginine in Experimentally Induced Myocardial Ischemia: Comparison With Aspirin"],"prefix":"10.1177","volume":"16","author":[{"given":"Alaaeldin I.","family":"Saleh","sequence":"first","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, German University in Cairo, New Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar M.","family":"Abdel Maksoud","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, German University in Cairo, New Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohda A.","family":"El-Maraghy","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Z.","family":"Gad","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, German University in Cairo, New Cairo, Egypt,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,10,11]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02014935"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00212-5"},{"key":"atypb3","volume-title":"Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview","author":"Shen, H.","year":"2009","edition":"1"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(78)90084-9"},{"issue":"5","key":"atypb5","first-page":"318","volume":"32","author":"Roy S.","year":"2000","journal-title":"Indian J Pharmacol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.79"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.11.2626"},{"issue":"5","key":"atypb9","first-page":"371","volume":"8","author":"Dass UN","year":"1992","journal-title":"Nutrition"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05582-H"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb12045.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.1.319"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.1.279"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(46)80130-6"},{"key":"atypb15","unstructured":"Piper PJ, Vane JR The release of prostaglandins during anaphylaxis in guinea-pig isolated lungs . In: Mantegazza P, Horton EW, eds. Prostaglandins, Peptides, and Amines. London, UK: Academic Press; 1969 :15-19."},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-2806(89)80003-9"},{"issue":"1","key":"atypb17","first-page":"87","volume":"61","author":"Gokkusu C.","year":"1991","journal-title":"Int Vitam Nutr Res"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115937"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200611010-00008"},{"issue":"2","key":"atypb20","first-page":"84","volume":"24","author":"Kela AK","year":"1980","journal-title":"Indian J Physiol Pharmacol"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)31214-7"},{"key":"atypb22","volume-title":"Clinical Guide to Laboratory Tests","author":"Tietz NW","year":"1995","edition":"3"},{"issue":"3","key":"atypb23","first-page":"131","volume":"15","author":"W\u00fcrzburg U.","year":"1977","journal-title":"J Clin Chem Clin Biochem"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00129-9"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1159\/000205234"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)90144-9"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1038\/194927b0"},{"key":"atypb28","volume-title":"Theory and Practice of Histological Techniques","author":"Banchroft JD","year":"1996","edition":"4"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.292"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.378"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00538-2"},{"issue":"3","key":"atypb32","first-page":"459","volume":"69","author":"Bloom S.","year":"1972","journal-title":"Am J Pathol"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.2176"},{"issue":"3","key":"atypb34","first-page":"333","volume":"33","author":"El-Maraghy SA","year":"2007","journal-title":"Arab J Med"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.32725\/jab.2008.024"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.10.054"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701230312"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.5.935"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05612-2"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199912000-00016"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90012-4"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(85)90350-0"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90125-R"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90264-4"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80042-3"},{"issue":"5","key":"atypb46","doi-asserted-by":"crossref","first-page":"471","DOI":"10.33549\/physiolres.930533","volume":"53","author":"Kraml P.","year":"2004","journal-title":"Physiol Res"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200611010-00008"},{"issue":"3","key":"atypb48","first-page":"269","volume":"37","author":"Yada T.","year":"2007","journal-title":"Clin Hemorheol Microcirc"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.4.333"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.8.716"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108132"},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.7.2080"},{"issue":"1","key":"atypb53","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0022-3565(25)21331-3","volume":"250","author":"Bjornsson TD","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.183707"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2006.2006"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615701"},{"key":"atypb57","first-page":"753","volume":"8","author":"Guo Y.","year":"2004","journal-title":"Chin J Clin Rehabil"},{"issue":"9098","key":"atypb58","first-page":"233","volume":"351","year":"1998","journal-title":"The Medical Research Council\u2019s General Practice Research Framework. Lancet"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90433-2"},{"key":"atypb60","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1282"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03414-2"},{"issue":"2","key":"atypb62","first-page":"147","volume":"51","author":"Kumar P.","year":"2007","journal-title":"Indian J Physiol Pharmacol"},{"issue":"1","key":"atypb63","first-page":"CR29","volume":"10","author":"Jablecka A.","year":"2004","journal-title":"Med Sci Monit"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.9994"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00523-8"},{"key":"atypb66","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.1.17"},{"key":"atypb67","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(97)00106-0"},{"issue":"3","key":"atypb68","first-page":"563","volume":"55","author":"Cylwik D.","year":"2004","journal-title":"J phys Pharmacol"},{"key":"atypb69","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1622"},{"key":"atypb70","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92372-9"},{"key":"atypb71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506595102"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248410378506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248410378506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:38:47Z","timestamp":1777394327000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1074248410378506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,11]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1177\/1074248410378506"],"URL":"https:\/\/doi.org\/10.1177\/1074248410378506","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,11]]}}}