{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:40:03Z","timestamp":1779205203695,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>This study evaluated the effect of telmisartan, ramipril, and amlodipine on atrial fibrillation (AF) recurrence and severity in hypertensive patients with metabolic syndrome. A total of 391 hypertensive outpatients with metabolic syndrome, in sinus rhythm but with at least 2 episodes of AF in the previous 6 months were randomized to telmisartan, ramipril, or amlodipine for 1 year. At the first AF, ventricular rate (VR) and plasma cardiac troponin I (TnI) were evaluated. P-wave dispersion (PWD) and procollagen type I carboxy-terminal peptide (PIP) were evaluated before and after 12 months of treatment. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similarly and significantly reduced by all treatments ( P &lt; .001). In all, 49% of patients treated with amlodipine had a recurrence of AF as did 25.5% of patients with ramipril and 12.9% of patients with telmisartan ( P &lt; .01 vs amlodipine and P &lt; .05 vs ramipril). Ventricular rate and TnI at the first AF recurrence were significantly lower with telmisartan and ramipril than with amlodipine. P-wave dispersion was reduced by ramipril (\u22125.1 ms, P &lt; .05) and even more by telmisartan (\u221211 ms, P &lt; .01). Telmisartan and ramipril induced a similar PIP reduction (\u221252.8 and \u221249.8 \u00b5g\/L, respectively, P &lt; .01). These findings suggested that in these patients telmisartan was more effective than ramipril in reducing AF recurrence and severity as well as in improving PWD, despite a similar BP reduction and a similar improvement in cardiac fibrosis. This could be related to a specific effect of telmisartan on atrial electric remodeling.<\/jats:p>","DOI":"10.1177\/1074248410395018","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T22:39:01Z","timestamp":1298068741000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Telmisartan and Ramipril on Atrial Fibrillation Recurrence and Severity in Hypertensive Patients With Metabolic Syndrome and Recurrent Symptomatic Paroxysmal and Persistent Atrial Fibrillation"],"prefix":"10.1177","volume":"17","author":[{"given":"Roberto","family":"Fogari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amedeo","family":"Mugellini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Zoppi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Preti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Destro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierangelo","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Derosa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Centro per l\u2019ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,18]]},"reference":[{"key":"bibr1-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00583-9"},{"key":"bibr2-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01253-6"},{"key":"bibr3-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.252"},{"key":"bibr4-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.744466"},{"key":"bibr5-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"bibr6-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"bibr7-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.02.050"},{"key":"bibr8-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.21.2322"},{"key":"bibr9-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi350"},{"key":"bibr10-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.04.026"},{"key":"bibr11-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.87"},{"issue":"1","key":"bibr12-1074248410395018","first-page":"21","volume":"20","author":"Nattel S","year":"2005","journal-title":"Curr Opin Cardiol"},{"key":"bibr13-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00178-9"},{"key":"bibr14-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.015347"},{"key":"bibr15-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1177\/1753944708092111"},{"key":"bibr16-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.24.2765"},{"key":"bibr17-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.10.1062"},{"key":"bibr18-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.23.2678"},{"key":"bibr19-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000124487.36586.26"},{"key":"bibr20-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/hc4601.099402"},{"key":"bibr21-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.070"},{"key":"bibr22-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.01.007"},{"key":"bibr23-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000022665.18619.83"},{"key":"bibr24-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.08.014"},{"key":"bibr25-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.023069"},{"key":"bibr26-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl135"},{"key":"bibr27-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000193808.99773.28"},{"key":"bibr28-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805710"},{"key":"bibr29-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.217"},{"key":"bibr30-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801317"},{"key":"bibr31-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917100-00015"},{"key":"bibr32-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2001.tb00101.x"},{"key":"bibr33-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1450"},{"key":"bibr34-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.098549"},{"issue":"4","key":"bibr35-1074248410395018","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/clinchem\/39.4.635","volume":"39","author":"Risteli J","year":"1993","journal-title":"Clin Chem"},{"key":"bibr36-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.6.535"},{"issue":"7","key":"bibr37-1074248410395018","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/clinchem\/36.7.1328","volume":"36","author":"Meikko J","year":"1990","journal-title":"Clin Chem"},{"key":"bibr38-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(01)00456-5"},{"issue":"31","key":"bibr39-1074248410395018","first-page":"439","volume":"133","author":"Zellweger MJ","year":"2003","journal-title":"Swiss Med Wkly"},{"issue":"3","key":"bibr40-1074248410395018","first-page":"172","volume":"8","author":"Kanjwal K","year":"2008","journal-title":"Indian Pacing Electrophysiol J"},{"key":"bibr41-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.07.120"},{"key":"bibr42-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-008-0034-x"},{"key":"bibr43-1074248410395018","doi-asserted-by":"publisher","DOI":"10.2143\/AC.63.4.2033044"},{"issue":"1","key":"bibr44-1074248410395018","first-page":"e1","volume":"14","author":"Anis RR.","year":"2009","journal-title":"Exp Clin Cardiol"},{"key":"bibr45-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1199"},{"key":"bibr46-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.01.006"},{"issue":"5","key":"bibr47-1074248410395018","first-page":"643","volume":"117","author":"Li Y","year":"2004","journal-title":"Chin Med J"},{"key":"bibr48-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137118.47943.5C"},{"key":"bibr49-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0571-2"},{"key":"bibr50-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00243-2"},{"key":"bibr51-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/hy0302.105683"},{"key":"bibr52-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00839.x"},{"key":"bibr53-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960280609"},{"key":"bibr54-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200007000-00010"},{"key":"bibr55-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.045"},{"key":"bibr56-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.09.015"},{"key":"bibr57-1074248410395018","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383719"},{"key":"bibr58-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.12.010"},{"key":"bibr59-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1083811"},{"key":"bibr60-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000123072.34629.57"},{"key":"bibr61-1074248410395018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61242-8"},{"issue":"1","key":"bibr62-1074248410395018","first-page":"41","volume":"25","author":"Kakuta H","year":"2005","journal-title":"Int J Clin Pharmacol Res"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248410395018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1074248410395018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248410395018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:38:56Z","timestamp":1777394336000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1074248410395018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,18]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1177\/1074248410395018"],"URL":"https:\/\/doi.org\/10.1177\/1074248410395018","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,18]]}}}