{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:26:29Z","timestamp":1778876789348,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T00:00:00Z","timestamp":1312848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Severe aortic stenosis due to calcification of the aortic valve is the most common indication for aortic valve replacement in the United States and Europe. The standard therapy for symptomatic patients with severe aortic stenosis is replacement of the valve. Some of the risk factors and pathophysiologic mechanisms in atherosclerosis play an important role in the development of calcific aortic stenosis. In the last few years, there have been an increased number of publications regarding the use of medications in order to delay the progression of aortic stenosis. These medications include statins, angiotensin-converting enzyme inhibitors, and biphosphanates. This article describes and summarizes some of the medical approaches that have emerged to alter the progression of aortic stenosis. Currently, only statins have been evaluated in randomized, placebo-control trials. Furthermore, statins have not proven to alter the progression of aortic stenosis. Ongoing randomized controlled trials with the use of angiotensin-converting enzyme inhibitors, statins, and biphosphonates will determine the use of these medications to delay the progression of aortic stenosis.<\/jats:p>","DOI":"10.1177\/1074248411416504","type":"journal-article","created":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T00:45:16Z","timestamp":1312937116000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Medical Therapy for Calcific Aortic Stenosis"],"prefix":"10.1177","volume":"17","author":[{"given":"Maria J.","family":"Salas","sequence":"first","affiliation":[{"name":"Division of Cardiology, Mount Sinai Heart Institute, Columbia University, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Santana","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mount Sinai Heart Institute, Columbia University, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Escolar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mount Sinai Heart Institute, Columbia University, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gervasio A.","family":"Lamas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mount Sinai Heart Institute, Columbia University, Miami Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,8,9]]},"reference":[{"key":"bibr1-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00563-3"},{"key":"bibr2-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60211-7"},{"key":"bibr3-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008313430903"},{"key":"bibr4-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.156752"},{"key":"bibr5-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098249"},{"key":"bibr6-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.11.033"},{"key":"bibr7-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0827"},{"key":"bibr8-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1080\/07853890802331394"},{"key":"bibr9-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H206"},{"key":"bibr10-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.844"},{"key":"bibr11-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sun014"},{"key":"bibr12-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01821-5"},{"key":"bibr13-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02496-8"},{"key":"bibr14-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.072"},{"key":"bibr15-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043876"},{"key":"bibr16-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804602"},{"key":"bibr17-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.900027"},{"key":"bibr18-1074248411416504","unstructured":"Principal investigator: Griffin, B. The Cleveland Clinic. The effect of statin therapy (Atorvastatin) on the progression of calcific valvular aortic stenosis. Clinicaltrial gov NCT00590135."},{"key":"bibr19-1074248411416504","unstructured":"Principal investigator: Sanchez, P. Hospital Universitario Gregorio Mara\u00f1\u00f3n de Madrid. Double blind randomized phase IV clinical trial to evaluate the efficacy of gluvastatin on inflammatory markers in the haemodynamic progression of degenerative aortic stenosis. The AORTICA 1 Study. Clinicaltrial gov NCT00404287."},{"key":"bibr20-1074248411416504","unstructured":"Walther C. University of Leipzig. Statin therapy in asymptomatic aortic stenosis. Clinicaltrial gov NCT00176410."},{"key":"bibr21-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001260"},{"key":"bibr22-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140723.15274.53"},{"key":"bibr23-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.486738"},{"key":"bibr24-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.066852"},{"key":"bibr25-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.858"},{"key":"bibr26-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1177\/108155890405200334"},{"key":"bibr27-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.047233"},{"key":"bibr28-1074248411416504","unstructured":"Rigshospitalet, Denmark. Acute haemodynamic effects of treatment with Ace-inhibitors in patients with symptomatic aortic stenosis (ACCESS). Clinicaltrial gov NCT00252317."},{"key":"bibr29-1074248411416504","unstructured":"Kupari M. Helsinki University Central Hospital. The Potential of Candesartan to Retard the Progression of Aortic Stenosis Influences of Medical Therapy to the Atheroinflammatory Process in Stenotic Aortic Valves. Clinicaltrial gov NCT00699452."},{"key":"bibr30-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070591.21548.69"},{"key":"bibr31-1074248411416504","doi-asserted-by":"crossref","unstructured":"Vattikuti R, Towler DA. Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab. 2004;286(5):E686\u2013E696.","DOI":"10.1152\/ajpendo.00552.2003"},{"key":"bibr32-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1324"},{"key":"bibr33-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.6.635"},{"key":"bibr34-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-90004-3"},{"issue":"7","key":"bibr35-1074248411416504","first-page":"711","volume":"4","author":"Reszka AA","year":"2004","journal-title":"Mini Rev Med Chem"},{"key":"bibr36-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.09.029"},{"key":"bibr37-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9104-y"},{"key":"bibr38-1074248411416504","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.02.051"},{"key":"bibr39-1074248411416504","unstructured":"\\Frontera G. Hospital Universitario Son Duret. Value of oral phytate (InsP6) in the prevention of progression of the cardiovascular calcifications (CALCIFICA). Clinicaltrial.gov NCT01000233."},{"key":"bibr40-1074248411416504","unstructured":"Koos R. RWTH Aachen University. Vitamin K Supplement for Inhibition of the Progress in Aortic Valve Calcification. Clinicaltrial gov NCT00785109."}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248411416504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1074248411416504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248411416504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:39:00Z","timestamp":1777394340000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1074248411416504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,9]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1177\/1074248411416504"],"URL":"https:\/\/doi.org\/10.1177\/1074248411416504","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,9]]}}}