{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:20:03Z","timestamp":1777530003769,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Cardiovascular complications represent a major cause of morbidity and mortality in patients undergoing vascular surgery. This was a prospective randomized, open-label study to investigate the effect of lipid-lowering treatment by statin monotherapy or intensified by combining statin with ezetimibe on a \u00a012-month\u00a0 prognosis after vascular surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients were randomly assigned to receive rosuvastatin (RSV) 10 mg\/d or rosuvastatin 10 mg\/d plus ezetemibe (RSV\/EZT) 10 mg\/d, starting prior to scheduled surgical procedure. The primary end point was the first major cardiovascular event, including death from cardiac causes, nonfatal myocardial infarction, ischemic stroke, and unstable angina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 136 patients assigned to RSV and 126 to RSV\/EZT completed the study protocol. As many as 6.6% of patients in the RSV group experience a major cardiovascular event within 30 days after surgery versus 5.6% in the RSV\/EZT group ( P = .72). From month 1 to 12 of the follow-up period, primary end point was observed (9 taking RSV vs 2 in the RSV\/EZT group [ P = .04]). Intensified lipid-lowering therapy with RSV\/EZT was associated with a greater decrease in low-density lipoprotein cholesterol levels compared with RSV (75.87 \u00b1 31.64 vs 87.19 \u00b1 31.7, P = .004), while no differential effect on triglyceride, high-density lipoprotein cholesterol or high-sensitivity C-reactive protein levels was noted between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings indicate that statin therapy intensified by ezetimibe may reduce the incidence of cardiovascular events within the first 12 months after vascular surgery. Nonetheless, whether the use of ezetimibe as an add-on therapy to reduce cardiovascular risk in these patients needs to be tested in larger future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248412445506","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T01:26:08Z","timestamp":1336613168000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of Rosuvastatin With or Without Ezetimibe on Clinical Outcomes in Patients Undergoing Elective Vascular Surgery"],"prefix":"10.1177","volume":"18","author":[{"given":"George N.","family":"Kouvelos","sequence":"first","affiliation":[{"name":"Department of Surgery\u2013Vascular Surgery Unit, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni M.","family":"Arnaoutoglou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miltiadis I.","family":"Matsagkas","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2013Vascular Surgery Unit, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kostara","sequence":"additional","affiliation":[{"name":"Department of Laboratory of Clinical Chemistry, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantina","family":"Gartzonika","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni T.","family":"Bairaktari","sequence":"additional","affiliation":[{"name":"Department of Laboratory of Clinical Chemistry, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haralampos J.","family":"Milionis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,9]]},"reference":[{"key":"bibr1-1074248412445506","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76.s4.13"},{"key":"bibr2-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.03.014"},{"key":"bibr3-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198402000-00016"},{"key":"bibr4-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.01.004"},{"key":"bibr5-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.048"},{"key":"bibr6-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.01.028"},{"key":"bibr7-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808207"},{"key":"bibr8-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.04.032"},{"key":"bibr9-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.009"},{"key":"bibr10-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.01.024"},{"key":"bibr11-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60739-3"},{"key":"bibr12-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1177\/000331970505600510"},{"key":"bibr13-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02610-4"},{"key":"bibr14-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200205000-00002"},{"key":"bibr15-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050461"},{"key":"bibr16-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.19.2437"},{"key":"bibr17-1074248412445506","doi-asserted-by":"publisher","DOI":"10.2165\/13168600-000000000-00000"},{"key":"bibr18-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.jpc60002"},{"key":"bibr19-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.10.022"},{"key":"bibr20-1074248412445506","doi-asserted-by":"publisher","DOI":"10.2217\/1745509X.3.6.691"},{"key":"bibr21-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1177\/0003319709356422"},{"key":"bibr22-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02394.x"},{"key":"bibr23-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.10.005"},{"key":"bibr24-1074248412445506","doi-asserted-by":"publisher","DOI":"10.5551\/jat.10835"},{"key":"bibr25-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1159\/000088105"},{"key":"bibr26-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.12.067"},{"key":"bibr27-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000164260.82417.3F"},{"key":"bibr30-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq181"},{"key":"bibr28-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800742"},{"key":"bibr29-1074248412445506","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804602"}],"container-title":["Journal 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