{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:04:11Z","timestamp":1793289851627,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF). Our purpose was to evaluate the comparative effect on urine output (UO) and renal function between these regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective study of hospitalized HF patients treated with continuous infusion furosemide (CIF), combination furosemide plus metolazone (F + M), or continuous infusion bumetanide (CIB). Primary end points were between regimen comparisons for change in mean hourly UO versus baseline and incidence of worsening renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Data on 242 patients with acute HF (age 58 \u00b1 12 years, 63% male, left ventricular ejection fraction 38% \u00b1 17%) were analyzed (160 CIF, 42 F + M, 40 CIB). The mean duration of diuretic regimens was 41 \u00b1 32 hours. Compared to baseline, all regimens increased mean hourly UO ( P &lt; .0001 for all), with greater increases with F + M (109 \u00b1 171 mL) and CIB (90 \u00b1 90 mL) compared to CIF (48 \u00b1 103 mL; P = .009). Incidence of worsening renal function was not different between regimens; however, blood urea nitrogen (BUN) tended to increase more with F + M (4.4 \u00b1 9.8 mg\/dL) and CIB (4.3 \u00b1 9.7 mg\/dL) than CIF (1.8 \u00b1 10.8 mg\/dL), P = .09. The incidence of hyponatremia was higher with F + M and CIB. Differences in UO, BUN, and hyponatremia were retained in the subgroup analysis limited to patients with baseline serum creatinine &lt;1.5 mg\/dL, where renal function between the groups was not different.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Compared to CIF, F + M or CIB was associated with greater increases in UO. No difference in the incidence of worsening renal function was found; however, electrolyte abnormalities may be more prevalent when furosemide is combined with metolazone or when bumetanide is used. These therapeutic differences warrant prospective study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248413482755","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T20:21:17Z","timestamp":1364502077000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of Bumetanide- and Metolazone-Based Diuretic Regimens to Furosemide in Acute Heart Failure"],"prefix":"10.1177","volume":"18","author":[{"given":"Tien M. H.","family":"Ng","sequence":"first","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Konopka","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alifiya F.","family":"Hyderi","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenche","family":"Hshieh","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron I.","family":"Jeng","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Lou","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Elkayam","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy and Keck School of Medicine, Los Angeles, CA, 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