{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:20:50Z","timestamp":1777530050257,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>According to the literature, estradiol has a direct vasodilator action by means of endothelium-derived relaxing factor synthesis. The present study aims to evaluate the acute hemodynamic effects of intranasal 17-\u03b2-estradiol on cerebral and lower limb arterial circulation in postmenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixteen healthy women in natural menopause (mean age: 54 \u00b1 3 years) were investigated for at least 6 months, each receiving 300 \u00b5g of intranasal 17-\u03b2-estradiol. We evaluated the heart rate, systolic\/diastolic blood pressure, peak systolic velocity, end-diastolic velocity, and velocity\u2013time integral (VTI) at the level of internal carotid and posterior tibial arteries, before and after 30, 60, and 180 minutes of drug administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After intranasal 17-\u03b2-estradiol administration, the internal carotid artery VTI showed statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05) variations at all the time intervals after administration of the drug (30, 60, and 180 minutes) when compared with \u201ctime zero\u201d (T0, ie, the speed recorded at baseline before drug administration). No significant variation was found at the posterior tibial artery. The systolic\/diastolic blood pressure and heart rate did not significantly differ before and after drug administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The administration of a single intranasal dose of 17-\u03b2-estradiol in healthy postmenopausal women increased cerebral perfusions, whereas the effect on peripheral circulation was much more limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248413484385","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T20:16:08Z","timestamp":1367007368000},"page":"354-358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Systemic Vascular Hemodynamic Changes due to 17-\u03b2-Estradiol Intranasal Administration"],"prefix":"10.1177","volume":"18","author":[{"given":"Marco Matteo","family":"Ciccone","sequence":"first","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Scicchitano","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Gesualdo","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fara","family":"Fornarelli","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology I, Bari University Hospital, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Farinola","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Cassano Murge, IRCCS Fondazione Salvatore Maugeri, Cassano Murge, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Lagioia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Cassano Murge, IRCCS Fondazione Salvatore Maugeri, Cassano Murge, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Sassara","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annapaola","family":"Zito","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Federici","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Human Physiology, Medical School, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Cicinelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology I, Bari University Hospital, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906103402306"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.1.252"},{"issue":"13","key":"e_1_3_2_4_2","first-page":"53","article-title":"Hormone replacement therapy and coronary artery atherosclerosis: the monkey model","volume":"103","author":"Clarkson TB","year":"1996","unstructured":"Clarkson TB, Anthony MS, Klein KP. Hormone replacement therapy and coronary artery atherosclerosis: the monkey model. Br J Obstet Gynaecol. 1996;103(suppl 13):53\u201357.","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11320"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322007000100012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.191221"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.2795"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.093542"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200201030-00006"},{"issue":"3","key":"e_1_3_2_11_2","first-page":"189","article-title":"Aerodiol: the efficacy and tolerability of intranasal estrogen administration. An overview [in Italian]","volume":"55","author":"Genazzani AR","year":"2003","unstructured":"Genazzani AR, Cappagli B, Ciaponi M. Aerodiol: the efficacy and tolerability of intranasal estrogen administration. An overview [in Italian]. Minerva Ginecol. 2003;55(3):189\u2013200.","journal-title":"Minerva Ginecol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00545-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.12.3060"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01786-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21924"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2000.pto870606.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.30"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.03.028"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2009-0467"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.022"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.081554"},{"issue":"5","key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"E882","DOI":"10.1152\/ajpendo.00037.2011","article-title":"Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle","volume":"301","author":"Yu X","year":"2011","unstructured":"Yu X, Ma H, Barman SA, . Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. 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