{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:21:38Z","timestamp":1777530098144,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated atorvastatin reloading effects on endothelial progenitor cell (EPC) count and inflammatory cytokine expression after percutaneous coronary intervention (PCI) in patients with stable angina pectoris who had previously received long-term statin treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with stable angina pectoris were treated with 80 mg atorvastatin 12 hours and 40 mg atorvastatin 2 hours before coronary angioplasty (n = 15) or preoperatively with 40 mg\/d atorvastatin for 7 days (n = 15) or did not receive atorvastatin (n = 15). CD45\u2212\/133+\/34+, CD45\u2212\/CD34+\/kinase insert domain receptor (KDR)+, and CD45\u2212\/CD144+\/KDR+ EPCs in the peripheral blood were determined by flow cytometry 1 hour before as well as 1 hour, 6 hours, and 24 hours after PCI. Soluble intercellular adhesion molecule 1 (sICAM-1), hypersensitive C-reactive protein (hCRP), and troponin-I (TnI) serum concentrations were analyzed immediately prior to and 24 hours after PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the 40mg Atorvastatin and control groups, none of the analyzed EPC blood concentrations changed significantly from 1h before operation to 1h and 6 h postoperative values. In contrast, the number of circulating early differentiation stage EPCs CD45-\/133+\/34+ and CD45-\/CD34+\/ KDR+ raised significantly from 1 h preoperative values (57.3\u00b19.3; 57.3 \u00b1 10.7) to 1 h postoperative ((74.4 \u00b1 11.4; 78.8 \u00b1 16.2), (p &lt; 0.05)) and 6 h postoperative ((93 \u00b1 16.9; 99.7 \u00b1 11.9), (p &lt; 0.05)) concentrations after coronary angioplasty in the 80mg Atorvastatin medication patients. In the control group, the sICAM-1 (174.55 \u00b1 38.91 vs 204.11 \u00b1 58.24) and hCRP (1.89 \u00b1 1.93 vs 9.0 \u00b1 11.1) serum concentrations at 24 hours after PCI were significantly elevated ( P &lt; .05) compared to preoperative values, whereas the increases in the 2 groups treated with atorvastatin were not significant. In addition, the rise in serum TnI concentration level from pre- to postoperative in the 80-mg (0.02 \u00b1 0.02 vs 0.09 \u00b1 0.08) and the 40-mg (0.01 \u00b1 0.03 vs 1.2 \u00b1 2.59) reloading groups was less than that of the controls (0.01 \u00b1 0.02 vs 1.75 \u00b1 3.09) (p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results suggested that high-dose atorvastatin application before PCI triggered early EPC circulation. Furthermore, postoperative inflammatory cytokine sICAM-1 as well as hCRP serum levels were reduced, while postinterventional myocardial injury marker TnI elevations were inversely correlated with statin reloadings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248413513500","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T21:30:48Z","timestamp":1387315848000},"page":"290-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["High-Dose Atorvastatin Reloading Before Percutaneous Coronary Intervention Increased Circulating Endothelial Progenitor Cells and Reduced Inflammatory Cytokine Expression During the Perioperative Period"],"prefix":"10.1177","volume":"19","author":[{"given":"Honghua","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuwei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanru","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yewen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ningbo First Hospital, the Affiliated Hospital of School of Medcine of Ningbo University, Ningbo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"bibr1-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1608"},{"issue":"3","key":"bibr2-1074248413513500","first-page":"301","volume":"61","author":"Wojakowski W","year":"2013","journal-title":"Minerva Cardioangiol"},{"key":"bibr3-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080564"},{"key":"bibr4-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00193-X"},{"key":"bibr5-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2745fje"},{"issue":"1","key":"bibr6-1074248413513500","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/HPC.0b013e3181980f9f","volume":"8","author":"Pollack CV","year":"2009","journal-title":"Crit Pathw Cardiol"},{"key":"bibr7-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.03.005"},{"key":"bibr8-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137828.06205.87"},{"key":"bibr9-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.3.607"},{"key":"bibr10-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"bibr11-1074248413513500","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.26.20120052"},{"key":"bibr12-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302949"},{"issue":"2","key":"bibr13-1074248413513500","first-page":"211","volume":"61","author":"Scacciatella P","year":"2013","journal-title":"Minerva Cardioangiol"},{"key":"bibr14-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0996"},{"key":"bibr15-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.028"},{"key":"bibr16-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1161\/hc2401.092816"},{"key":"bibr17-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.05.031"},{"key":"bibr18-1074248413513500","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0441"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248413513500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1074248413513500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248413513500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:41:56Z","timestamp":1777394516000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1074248413513500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/1074248413513500"],"URL":"https:\/\/doi.org\/10.1177\/1074248413513500","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}