{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:22:57Z","timestamp":1777530177759,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oxidative stress may play an important role in the development of myocarditis. We investigated the effects of N-acetylcysteine (NAC), a potent antioxidant, on experimental autoimmune myocarditis (EAM) in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      A rat model of porcine myosin-induced EAM was used. After the immunization with myosin, NAC (20 mg\/kg\/d) or saline was injected intraperitoneally on days 1 to 21. Additional myosin-immunized rats treated with NAC were orally given 25 mg\/kg\/d of N\n                      <jats:sup>G<\/jats:sup>\n                      -nitro-l-arginine methylester (l-NAME), an inhibitor of nitric oxide (NO) synthase, and N\n                      <jats:sup>G<\/jats:sup>\n                      -nitro-d-arginine methylester (d-NAME), an inactive enantiomer. The NAC treatment improved cardiac pathology associated with reduced superoxide production. In the EAM rats treated with NAC associated with oral l-NAME, but not with oral d-NAME, the severity of myocarditis was not reduced. Expression of intercellular adhesion molecule 1 was reduced by NAC treatment. Myocardial c-kit\n                      <jats:sup>+<\/jats:sup>\n                      cells were demonstrated only in the NAC-treated group. Hemodynamic study showed that the increased left ventricular mass produced by myocardial inflammation tended to be reduced by NAC treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Treatment with NAC ameliorated myocardial injury via NO system in a rat model of myocarditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248414547574","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T23:58:49Z","timestamp":1408665529000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>N<\/i>\n                    -Acetylcysteine Ameliorates Experimental Autoimmune Myocarditis in Rats via Nitric Oxide"],"prefix":"10.1177","volume":"20","author":[{"given":"Kana","family":"Shimada","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Uzui","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Ueda","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Dae","family":"Lee","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medical Science, University of Fukui, Fukui, 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